Condition category
Circulatory System
Date applied
29/09/2006
Date assigned
29/09/2006
Last edited
12/04/2012
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Rachael T Donohoe

ORCID ID

Contact details

London Ambulance Service NHS Trust - Headquarters Annexe
Ground Floor
8-20 Pocock Street
London
SE1 0BW
United Kingdom
+44 020 7463 3126
rachael.donohoe@lond-amb.nhs.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

NCT00219687

Protocol/serial number

N0352143844

Study information

Scientific title

Dispatcher-Assisted Resuscitation Trial

Acronym

DART

Study hypothesis

Is telephone-assisted CPR with chest compressions only better than telephone-assisted CPR with ventilation and compressions? Which protocol will save more lives?

Ethics approval

Added 24 July 2008:
Approved by Lewisham Research Ethics Committee (UK) on 04/08/2004. Reference 04/Q0701/07.

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

No information is supplied to patients as they are in cardiac arrest when enrolled in the study. The protocol is fully approved by a Research Ethics Committee and is compliant with relevant legislation relating to trials in emergency situations.

Condition

Cardiovascular: Cardiac arrest

Intervention

Dispatcher-assisted CPR instructions with compressions and ventilations versus dispatcher-assisted CPR instructions with compressions only

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Survival to hospital discharge

Secondary outcome measures

Added 24 July 2008:
Neurological status at hospital discharge (United States only).

Overall trial start date

01/06/2004

Overall trial end date

30/09/2008

Reason abandoned

Eligibility

Participant inclusion criteria

All cardiac arrest patients for whom the LAS is contacted, who are not breathing or conscious, and the caller is amenable to undertaking dispatcher-assisted CPR.

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

The total sample size for the study is approximately 1600 patients.

Participant exclusion criteria

1. Caller refusal to undertake CPR
2. CPR already in progress
3. Cases of cardiac arrest due to trauma, electrocution, hanging, drowning or strangulation
4. AED available for use
5. Vulnerable groups: <18 years, pregnant women, prisoners (if data is known)

Recruitment start date

01/06/2004

Recruitment end date

30/09/2008

Locations

Countries of recruitment

United Kingdom, United States of America

Trial participating centre

London Ambulance Service NHS Trust - Headquarters Annexe
London
SE1 0BW
United Kingdom

Sponsor information

Organisation

Record Provided by the NHSTCT Register - 2006 Update - Department of Health

Sponsor details

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)20 7307 2622
dhmail@doh.gsi.org.uk

Sponsor type

Government

Website

http://www.dh.gov.uk/Home/fs/en

Funders

Funder type

Government

Funder name

London Ambulance Service NHS Trust (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Funder name

NHS R&D Support Funding

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20818863

Publication citations

  1. Results

    Rea TD, Fahrenbruch C, Culley L, Donohoe RT, Hambly C, Innes J, Bloomingdale M, Subido C, Romines S, Eisenberg MS, CPR with chest compression alone or with rescue breathing., N. Engl. J. Med., 2010, 363, 5, 423-433, doi: 10.1056/NEJMoa0908993.

Additional files

Editorial Notes