A randomised double-blind prospective study to compare the intubating conditions with remifentanil (4 ug/mkg) and either propofol (2 mg/kg) or etomidate (0.3 mg/kg)

ISRCTN	ISRCTN84400696
DOI	https://doi.org/10.1186/ISRCTN84400696
Secondary identifying numbers	N0084113942

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr Ian McNeil
Scientific

Department of Anaesthesia
Hull Royal Infirmary
Anlaby Road
Hull
HU3 2 JZ
United Kingdom

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Scientific title	A randomised double-blind prospective study to compare the intubating conditions with remifentanil (4 ug/mkg) and either propofol (2 mg/kg) or etomidate (0.3 mg/kg)
Study objectives	1. To investigate whether there is a role for etomidate for intubation without muscle relaxants? 2. Is it more stable than propofol?
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Surgery: Intubation
Intervention	1. Remifentanil and etomidate 2. Remifentanil and propofol Both the patients and the intubating anaesthetist will be blinded to the induction agents administered by a second anaesthetist.
Intervention type	Drug
Pharmaceutical study type(s)
Phase	Not Applicable
Drug / device / biological / vaccine name(s)	Remifentanil, etomidate, propofol
Primary outcome measure	The end points are: 1. Intubating conditions 2. Cardiovascular stability
Secondary outcome measures	Not provided at time of registration
Overall study start date	01/08/2002
Completion date	01/06/2004

Participant type(s)	Patient
Age group	Adult
Lower age limit	18 Years
Upper age limit	65 Years
Sex	Both
Target number of participants	40
Key inclusion criteria	40 American Society of Anesthesiologists (ASA) 1 and 2 non-obese (Body Mass Index [BMI] <30) elective surgical patients aged between 18 and 65 years. They must require intubation for their proposed surgery.
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/08/2002
Date of final enrolment	01/06/2004

Hull Royal Infirmary

Hull
HU3 2 JZ
United Kingdom

Department of Health (UK)
Government

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Website	http://www.doh.gov.uk

Government

The North and South Bank Research and Development Consortium (UK)

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan