Contact information
Type
Scientific
Primary contact
Dr Emma Baker
ORCID ID
Contact details
St George's Hospital
University of London
Cranmer Terrace
Tooting
London
SW17 0RE
United Kingdom
+44 (0)20 8725 5383
ebaker@sgul.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0236143719
Study information
Scientific title
Acronym
Study hypothesis
To determine whether nasal application of phloridzin, a sodium-glucose co-transporter (SGLT-1) inhibitor, alters nasal potential difference demonstrating SGLT-1 function.
Ethics approval
Wandsworth REC (UK)
Study design
In vivo pharmacological study
Primary study design
Interventional
Secondary study design
Other
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Respiratory: Chronic obstructive pulmonary disease (COPD)
Intervention
Nasal potential difference: between the 'sensing' electrode in contact with the nasal epithelium, and the 'reference' electrode, a butterfly needle inserted under the skin of the forearm, is measured. Phloridzin in Ringer's solution will then be additionally perfused onto the nasal epithelium and any further change in nasal PD recorded. On a second visit a repeat of the above protocol will be carried out with phloridzin followed be amiloride.
Intervention type
Drug
Phase
Not Specified
Drug names
phloridzin
Primary outcome measures
Changes in the measured nasal potential difference with phloridzin
Secondary outcome measures
No secondary outcome measures
Overall trial start date
01/10/2002
Overall trial end date
01/12/2007
Reason abandoned
Not a clinical trial
Eligibility
Participant inclusion criteria
Healthy, non-smoking volunteers with normal nasal mucosa and random plasma glucose <7mmol/l.
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
10
Participant exclusion criteria
1. Nasal disease
2. Diabetes mellitus
3. Pregnancy
Recruitment start date
01/10/2002
Recruitment end date
01/12/2007
Locations
Countries of recruitment
United Kingdom
Trial participating centre
St George's Hospital
London
SW17 0RE
United Kingdom
Sponsor information
Organisation
Department of Health
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 (0)20 7307 2622
dhmail@doh.gsi.org.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
St George's Healthcare NHS Trust (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
No External Funding
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
NHS R&D Support Funding
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary