Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
YCS
Study information
Scientific title
Intracameral voriconazole injection in the treatment of fungal endophthalmitis developed from keratitis: a retrospective non-randomised non-controlled study
Acronym
Study hypothesis
Intracameral voriconazole administered may effectively treat fungal endophthalmitis located at anterior chamber.
Ethics approval
Taichung Veterans General Hospital (VGHTC) ethics board approved in 2009
Study design
Retrospective non-randomised non-controlled study
Primary study design
Interventional
Secondary study design
Non randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Fungal endophthalmitis developed from keratitis
Intervention
100 μg of voriconazole in 0.1 ml was injected into the anterior chamber using a 30-gauge needle attached to a 1.0 ml regular insulin syringe. Intracameral voriconazole injection was given once a day and the treatment discontinued while the eyes showed disappearance of the endothelial plaque and resolution of the anterior chamber fungal infiltrate. Patients diagnosed with filamentous fungal keratitis progressing to endophthalmitis who had undergone treatment with intracameral voriconazole injection and were followed up for at least 4 months.
Intervention type
Drug
Phase
Not Applicable
Drug names
Voriconazole
Primary outcome measures
Clinical observation, checked 1 month and 4 months after treatments
Secondary outcome measures
Checked 1 month and 4 months after treatments:
1. Visual acuity
2. Fungal infiltrate disappearance
Overall trial start date
01/01/2005
Overall trial end date
31/12/2008
Reason abandoned
Eligibility
Participant inclusion criteria
1. Fungal endophthalmitis from keratitis
2. Anterior chamber shows fungal web, fungal balls or endothelial plaque
3. Culture approved
4. Aged 38 - 78 years, either sex
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
10 patients
Participant exclusion criteria
1. Bacterial infection
2. Culture negative
3. Fungal infection from other source
Recruitment start date
01/01/2005
Recruitment end date
31/12/2008
Locations
Countries of recruitment
Taiwan
Trial participating centre
No. 160, Sec 3
Taichung
403
Taiwan
Sponsor information
Organisation
Taichung Veterans General Hospital (VGHTC) (Taiwan)
Sponsor details
No. 160
Sec 3
Taichung Port Road
Taichung
403
Taiwan
Sponsor type
Hospital/treatment centre
Website
Funders
Funder type
Hospital/treatment centre
Funder name
Taichung Veterans General Hospital (VGHTC) (Taiwan)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary