Central line insertion project (CLIP)

ISRCTN	ISRCTN85787933
DOI	https://doi.org/10.1186/ISRCTN85787933
Secondary identifying numbers	HTA 95/16/06

Submission date: 25/04/2003
Registration date: 25/04/2003
Last edited: 08/11/2022

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Other

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Ms Angela Boland
Scientific

University of Liverpool
Ashton Street Medical School
Ashton Street
Liverpool
L69 3GE
United Kingdom

Phone	+44 (0)151 794 5541
Email	a.boland@liv.ac.uk

Study information

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Not specified
Study type	Not Specified
Scientific title	Central line insertion project (CLIP)
Study acronym	CLIP
Study objectives	A single centre randomised trial of central venous catheter insertion by a clinical nurse specialist, under image guidance or on the ward without routine access to image guidance. Approximately 400 patients will be randomised to compare safety, adverse events, efficacy, quality of life and cost. The study will identify the incremental cost effectiveness ratio for nurse insertion and develop and evaluate a training programme to generalise these benefits throughout the NHS. A model will be developed to analyse the long term benefits for patients and the NHS from generalised adoption of the optimal methods of insertion throughout the NHS.
Ethics approval(s)	Not provided at time of registration.
Health condition(s) or problem(s) studied	Not applicable
Intervention	1. Central venous catheter insertion by a clinical nurse specialist under image guidance 2. Central venous catheter insertion on the ward without routine access to image guidance
Intervention type	Other
Primary outcome measure	Catheter-tip misplacement and this was expected to be higher in the blind arm. When comparing the skill level of the trainer and the trainees, pneumothorax was the primary clinical outcome measure.
Secondary outcome measures	Other outcomes measures included arterial puncture, haematoma, infection, failed insertion and assistance from other healthcare professionals.
Overall study start date	01/01/1999
Completion date	31/12/2000

Eligibility

Participant type(s)	Patient
Age group	Adult
Sex	Both
Target number of participants	400
Key inclusion criteria	Not provided at time of registration.
Key exclusion criteria	Not provided at time of registration.
Date of first enrolment	01/01/1999
Date of final enrolment	31/12/2000

Locations

Countries of recruitment

England
United Kingdom

Study participating centre

University of Liverpool

Liverpool
L69 3GE
United Kingdom

Sponsor information

Department of Health (UK)
Government

Quarry House
Quarry Hill
Leeds
LS2 7UE
United Kingdom

Phone	+44 (0)1132 545 843
Email	Sheila.Greener@doh.gsi.gov.uk
Website	http://www.dh.gov.uk/en/index.htm
"ROR"	https://ror.org/03sbpja79

Funders

Funder type

Government

NIHR Health Technology Assessment Programme - HTA (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan	Not provided at time of registration

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	HTA monograph	01/04/2003		Yes	No

Editorial Notes

08/11/2022: Internal review.