Contact information
Type
Scientific
Primary contact
Prof J G F Cleland
ORCID ID
Contact details
Academic Cardiology Department
Cardiology
Castle Hill Hospital
Hull
HU16 5JQ
United Kingdom
+44 (0)1482 624083
J.G.Cleland@hull.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0084160159
Study information
Scientific title
Acronym
SALT STUDY
Study hypothesis
To determine the effects of altering dietary sodium intake or daily physical activity on plasma concentrations of N-Terminal BNP in normal subjects and patients who have had a prior Q-wave MI.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Other
Trial type
Quality of life
Patient information sheet
Condition
Sodium intake
Intervention
The results of this trial will be used to inform clinical decision making based on NT_BNP results. Other areas involved: Cardiology, Nuclear Medicine Department.
The study is an open-label, randomised trial comparing the effects of varying dietary sodium and level of daily activity in 30 normal subjects patients recruited from General Practice and 30 patients with prior Q-wave myocardial infraction at the Nuclear Medicine Department at Hull Royal Infirmary.
Intervention type
Other
Phase
Not Applicable
Drug names
Primary outcome measures
Brain Natriuretic Peptides (BNP)
Secondary outcome measures
Not provided at time of registration
Overall trial start date
09/02/2005
Overall trial end date
09/04/2007
Reason abandoned
Lack of staff/facilities/resources
Eligibility
Participant inclusion criteria
1. 30 normal subjects over 60 years old
2. 30 mobile patients over 60 years old who have had a Q-wave MI and left ventricular ejection fraction (LVEF) less than 45%
Resources/Patient:
1. Electrocardiogram (ECG)
2. Echocardiography
3. Treadmill exercise with VO2 measurement for each patient
Participant type
Patient
Age group
Senior
Gender
Both
Target number of participants
60
Participant exclusion criteria
1. No angina
2. No heart failure
3. Not receiving diuretics
4. No renal impairment
Recruitment start date
09/02/2005
Recruitment end date
09/04/2007
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Academic Cardiology Department
Hull
HU16 5JQ
United Kingdom
Sponsor information
Organisation
Department of Health
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
+44 20 7307 2622
dhmail@doh.gsi.org.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
The North and South Bank Research and Development Consortium (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
NHS R&D Support Funding (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary