SALT STUDY: Effect of varying sodium intake and activity on plasma concentrations of N-Terminal BNP in normal subjects and patients with prior Q-wave myocardial infarction (MI)
| ISRCTN | ISRCTN88264942 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN88264942 |
| Secondary identifying numbers | N0084160159 |
- Submission date
- 30/09/2005
- Registration date
- 30/09/2005
- Last edited
- 19/07/2013
- Recruitment status
- Stopped
- Overall study status
- Stopped
- Condition category
- Nutritional, Metabolic, Endocrine
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof J G F Cleland
Scientific
Scientific
Academic Cardiology Department
Cardiology
Castle Hill Hospital
Hull
HU16 5JQ
United Kingdom
| Phone | +44 (0)1482 624083 |
|---|---|
| J.G.Cleland@hull.ac.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Other |
| Study type | Quality of life |
| Scientific title | |
| Study acronym | SALT STUDY |
| Study objectives | To determine the effects of altering dietary sodium intake or daily physical activity on plasma concentrations of N-Terminal BNP in normal subjects and patients who have had a prior Q-wave MI. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Sodium intake |
| Intervention | The results of this trial will be used to inform clinical decision making based on NT_BNP results. Other areas involved: Cardiology, Nuclear Medicine Department. The study is an open-label, randomised trial comparing the effects of varying dietary sodium and level of daily activity in 30 normal subjects patients recruited from General Practice and 30 patients with prior Q-wave myocardial infraction at the Nuclear Medicine Department at Hull Royal Infirmary. |
| Intervention type | Other |
| Primary outcome measure | Brain Natriuretic Peptides (BNP) |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 09/02/2005 |
| Completion date | 09/04/2007 |
| Reason abandoned (if study stopped) | Lack of staff/facilities/resources |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Senior |
| Sex | Both |
| Target number of participants | 60 |
| Key inclusion criteria | 1. 30 normal subjects over 60 years old 2. 30 mobile patients over 60 years old who have had a Q-wave MI and left ventricular ejection fraction (LVEF) less than 45% Resources/Patient: 1. Electrocardiogram (ECG) 2. Echocardiography 3. Treadmill exercise with VO2 measurement for each patient |
| Key exclusion criteria | 1. No angina 2. No heart failure 3. Not receiving diuretics 4. No renal impairment |
| Date of first enrolment | 09/02/2005 |
| Date of final enrolment | 09/04/2007 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Academic Cardiology Department
Hull
HU16 5JQ
United Kingdom
HU16 5JQ
United Kingdom
Sponsor information
Department of Health
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
| Phone | +44 (0)20 7307 2622 |
|---|---|
| dhmail@doh.gsi.org.uk | |
| Website | http://www.dh.gov.uk/Home/fs/en |
Funders
Funder type
Government
The North and South Bank Research and Development Consortium (UK)
No information available
NHS R&D Support Funding (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
