Strategies for the prevention of dengue (Estrategias para la prevencion del Dengue)

ISRCTN ISRCTN88405796
DOI https://doi.org/10.1186/ISRCTN88405796
Secondary identifying numbers DGCD-FA2-95900-4
Submission date
08/05/2008
Registration date
12/06/2008
Last edited
18/06/2009
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Prof Patrick Van der Stuyft
Scientific

Institute of Tropical Medicine
Epidemiology and Disease Control Unit, Public Health Department
Nationalestraat 155
Antwerp
2000
Belgium

Email pvdstuyft@itg.be

Study information

Study designSingle-centre cluster randomised controlled trial (blinding not possible).
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Other
Study typePrevention
Scientific titleA cluster randomised trial evaluating community involvement in Aedes control and dengue prevention
Study objectivesAn integrated community-based environmental management strategy is more effective in terms of reductions in entomological indices in comparison to routine Aedes control.
Ethics approval(s)Ethics Committee of the Pedro Kouri Institute (Comité de ética y revision del Instituto Pedro Kouri), Havana, Cuba (affiliated to the Ministry of Health [MINSAP]), approved in September 2003 (ref: 0103015)
Health condition(s) or problem(s) studiedAedes aegypti infestation/ dengue fever
InterventionIntervention communities: A community-based environmental management approach combined with the routine national dengue vector control programme. Dengue control activities were identified, designed, planned and executed by the community itself, with the support of newly set-up local Community Working Groups.
Control communities: Routine Aedes aegypti control programme (entomological surveillance, source reduction, selective adulticiding and health education)

Total duration of interventions/ follow-up: 13 months
Intervention typeOther
Primary outcome measureAedes infestation levels, assessed every 11 days over the total duratin of follow-up (13 months):
1. House Indices (HI): number of houses positive for at least one container with Aedes aegypti immature stages/100 inspected houses
2. Breteau Indices (BI): number of containers positive for Aedes aegypti immature stages/100 inspected houses
3. Pupal Indices (PI): number of Aedes aegypti pupae/inhabitant

In cycles of 11 days, the National Vector Control programme conducted routine entomological surveys in all dwellings of the municipality. This provided the entomological information for all clusters for the period of January 2005-February 2006.
Secondary outcome measures1. Proportion of breeding sites positive for first and second instar larvae. Data were collected as for the primary outcome measures every 11 days over 13 months.
2. Percentage of blocks (approximately 20-50 houses per block) repeatedly positive for larvae. Data were collected as for the primary outcome measures every 11 days over 13 months.
3. Level of community participation based on the Rifkin criteria, assessed 12 months after the start of interventions
Overall study start date01/09/2004
Completion date31/12/2007

Eligibility

Participant type(s)Patient
Age groupOther
SexBoth
Target number of participants32 circumscriptions of each approximately 500 houses
Key inclusion criteria1. Circumscriptions (i.e. neighbourhoods) of central urban Guantanamo
2. Community approval
Key exclusion criteria1. Circumscriptions without community approval
Date of first enrolment01/09/2004
Date of final enrolment31/12/2007

Locations

Countries of recruitment

  • Belgium
  • Cuba

Study participating centre

Institute of Tropical Medicine
Antwerp
2000
Belgium

Sponsor information

Directorate-General for Development Co-operation (DGDC) (Belgium)
Government

FOD Buitenlandse Zaken
Buitenlandse Handel en
Ontwikkelingssamenwerking
Karmelietenstraat 15
Brussels
1000
Belgium

Website http://www.dgic.be/en/index.html

Funders

Funder type

Government

Directorate-General for Development Co-operation (DGDC) (Belgium) (project ref: 95900) (framework agreement between the Institute of Tropical Medicine of Belgium and of Cuba)

No information available

Ministry of Health (MINSAP) (Cuba)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 09/06/2009 Yes No