Can Repellents Prevent Malaria in Africa?

ISRCTN	ISRCTN92202008
DOI	https://doi.org/10.1186/ISRCTN92202008
Secondary identifying numbers	NIMR/HQ/R8a/VolIX/780

Submission date: 29/01/2010
Registration date: 18/02/2010
Last edited: 21/08/2014

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Infections and Infestations

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Sarah Moore
Scientific

Disease Control and Vector Biology Unit (DCVBU)
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Email	sarah.moore@lshtm.ac.uk

Study information

Study design	Cluster controlled randomised trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Other
Study type	Treatment
Participant information sheet	Not available in web format, please use the contact details below to request a patient information sheet
Scientific title	Low cost repellents for use in rural Africa: a short-term efficacy, effectiveness and perceived benefit survey in Kilombero, Tanzania
Study acronym	CRPMA
Study objectives	As Tanzania progresses towards the goals of the Abuja declaration and insecticide-treated bed nets (ITN) coverage becomes almost universal, there is likely to be a selection pressure on malaria mosquitoes to feed outdoors and earlier in the evening when hosts are available. This coupled with changes in lifestyle such as increased access to electricity so people stay awake later means that the relative exposure of the population to infectious mosquito bites is likely to switch to earlier in the evening. A topical insect repellent containing deet can dramatically reduce malaria in South America and Southern Asia where vectors feed early in the evening. The project aims to measure the impact of such a repellent on clinical episodes of malaria in rural Africa.
Ethics approval(s)	1. Ifakara Health Institute Institutional Review Board, 10/11/2008, ref: IHRDC/IRB/No. A46 2. National Institute of Medical Research, Tanzania, 06/03/2009, ref: NIMR/HQ/R8a/VolIX/780
Health condition(s) or problem(s) studied	Malaria
Intervention	Long lasting insecticide treated nets (Olyset) + 15% deet repellent Long lasting insecticide treated nets (Olyset) + placebo lotion Total duration of intervention: 44 weeks Total duration of follow-up: 1 month after the trial ends
Intervention type	Drug
Pharmaceutical study type(s)
Phase	Not Applicable
Drug / device / biological / vaccine name(s)	Deet-containing insect repellent
Primary outcome measure	1. Malaria incidence 2. Clinical episodes of malaria Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
Secondary outcome measures	Malaria prevalence. Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
Overall study start date	30/08/2009
Completion date	30/07/2010

Eligibility

Participant type(s)	Patient
Age group	Adult
Lower age limit	18 Years
Sex	Both
Target number of participants	4819
Key inclusion criteria	Household head over 18 years, either sex
Key exclusion criteria	Under six months of age
Date of first enrolment	30/08/2009
Date of final enrolment	30/07/2010

Locations

Countries of recruitment

England
Tanzania
United Kingdom

Study participating centre

Disease Control and Vector Biology Unit (DCVBU)

London
WC1E 7HT
United Kingdom

Sponsor information

Ifakara Health Institute (Tanzania)
Research organisation

Box 53
Ifakara
53
Tanzania

Website	http://www.ihi.or.tz/
"ROR"	https://ror.org/04js17g72

Funders

Funder type

Research organisation

Population Services International (PSI) (Tanzania) - Innovations Grant

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	16/08/2014		Yes	No