ISRCTN ISRCTN92202008
DOI https://doi.org/10.1186/ISRCTN92202008
Secondary identifying numbers NIMR/HQ/R8a/VolIX/780
Submission date
29/01/2010
Registration date
18/02/2010
Last edited
21/08/2014
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Sarah Moore
Scientific

Disease Control and Vector Biology Unit (DCVBU)
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom

Email sarah.moore@lshtm.ac.uk

Study information

Study designCluster controlled randomised trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Other
Study typeTreatment
Participant information sheet Not available in web format, please use the contact details below to request a patient information sheet
Scientific titleLow cost repellents for use in rural Africa: a short-term efficacy, effectiveness and perceived benefit survey in Kilombero, Tanzania
Study acronymCRPMA
Study objectivesAs Tanzania progresses towards the goals of the Abuja declaration and insecticide-treated bed nets (ITN) coverage becomes almost universal, there is likely to be a selection pressure on malaria mosquitoes to feed outdoors and earlier in the evening when hosts are available. This coupled with changes in lifestyle such as increased access to electricity so people stay awake later means that the relative exposure of the population to infectious mosquito bites is likely to switch to earlier in the evening. A topical insect repellent containing deet can dramatically reduce malaria in South America and Southern Asia where vectors feed early in the evening. The project aims to measure the impact of such a repellent on clinical episodes of malaria in rural Africa.
Ethics approval(s)1. Ifakara Health Institute Institutional Review Board, 10/11/2008, ref: IHRDC/IRB/No. A46
2. National Institute of Medical Research, Tanzania, 06/03/2009, ref: NIMR/HQ/R8a/VolIX/780
Health condition(s) or problem(s) studiedMalaria
InterventionLong lasting insecticide treated nets (Olyset) + 15% deet repellent
Long lasting insecticide treated nets (Olyset) + placebo lotion

Total duration of intervention: 44 weeks
Total duration of follow-up: 1 month after the trial ends
Intervention typeDrug
Pharmaceutical study type(s)
PhaseNot Applicable
Drug / device / biological / vaccine name(s)Deet-containing insect repellent
Primary outcome measure1. Malaria incidence
2. Clinical episodes of malaria

Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
Secondary outcome measuresMalaria prevalence.

Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
Overall study start date30/08/2009
Completion date30/07/2010

Eligibility

Participant type(s)Patient
Age groupAdult
Lower age limit18 Years
SexBoth
Target number of participants4819
Key inclusion criteriaHousehold head over 18 years, either sex
Key exclusion criteriaUnder six months of age
Date of first enrolment30/08/2009
Date of final enrolment30/07/2010

Locations

Countries of recruitment

  • England
  • Tanzania
  • United Kingdom

Study participating centre

Disease Control and Vector Biology Unit (DCVBU)
London
WC1E 7HT
United Kingdom

Sponsor information

Ifakara Health Institute (Tanzania)
Research organisation

Box 53
Ifakara
53
Tanzania

Website http://www.ihi.or.tz/
ROR logo "ROR" https://ror.org/04js17g72

Funders

Funder type

Research organisation

Population Services International (PSI) (Tanzania) - Innovations Grant

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 16/08/2014 Yes No