Contact information
Type
Scientific
Primary contact
Dr Sarah Moore
ORCID ID
Contact details
Disease Control and Vector Biology Unit (DCVBU)
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
sarah.moore@lshtm.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
NIMR/HQ/R8a/VolIX/780
Study information
Scientific title
Low cost repellents for use in rural Africa: a short-term efficacy, effectiveness and perceived benefit survey in Kilombero, Tanzania
Acronym
CRPMA
Study hypothesis
As Tanzania progresses towards the goals of the Abuja declaration and insecticide-treated bed nets (ITN) coverage becomes almost universal, there is likely to be a selection pressure on malaria mosquitoes to feed outdoors and earlier in the evening when hosts are available. This coupled with changes in lifestyle such as increased access to electricity so people stay awake later means that the relative exposure of the population to infectious mosquito bites is likely to switch to earlier in the evening. A topical insect repellent containing deet can dramatically reduce malaria in South America and Southern Asia where vectors feed early in the evening. The project aims to measure the impact of such a repellent on clinical episodes of malaria in rural Africa.
Ethics approval
1. Ifakara Health Institute Institutional Review Board, 10/11/2008, ref: IHRDC/IRB/No. A46
2. National Institute of Medical Research, Tanzania, 06/03/2009, ref: NIMR/HQ/R8a/VolIX/780
Study design
Cluster controlled randomised trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Other
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Malaria
Intervention
Long lasting insecticide treated nets (Olyset) + 15% deet repellent
Long lasting insecticide treated nets (Olyset) + placebo lotion
Total duration of intervention: 44 weeks
Total duration of follow-up: 1 month after the trial ends
Intervention type
Drug
Phase
Not Applicable
Drug names
Deet-containing insect repellent
Primary outcome measure
1. Malaria incidence
2. Clinical episodes of malaria
Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
Secondary outcome measures
Malaria prevalence.
Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
Overall trial start date
30/08/2009
Overall trial end date
30/07/2010
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Household head over 18 years, either sex
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
4819
Participant exclusion criteria
Under six months of age
Recruitment start date
30/08/2009
Recruitment end date
30/07/2010
Locations
Countries of recruitment
Tanzania
Trial participating centre
Disease Control and Vector Biology Unit (DCVBU)
London
WC1E 7HT
United Kingdom
Sponsor information
Organisation
Ifakara Health Institute (Tanzania)
Sponsor details
Box 53
Ifakara
53
Tanzania
Sponsor type
Research organisation
Website
Funders
Funder type
Research organisation
Funder name
Population Services International (PSI) (Tanzania) - Innovations Grant
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/25129515
Publication citations
-
Results
Sangoro O, Turner E, Simfukwe E, Miller JE, Moore SJ, A cluster-randomized controlled trial to assess the effectiveness of using 15% DEET topical repellent with long-lasting insecticidal nets (LLINs) compared to a placebo lotion on malaria transmission., Malar. J., 2014, 13, 1, 324, doi: 10.1186/1475-2875-13-324.