Can Repellents Prevent Malaria in Africa?
ISRCTN | ISRCTN92202008 |
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DOI | https://doi.org/10.1186/ISRCTN92202008 |
Secondary identifying numbers | NIMR/HQ/R8a/VolIX/780 |
- Submission date
- 29/01/2010
- Registration date
- 18/02/2010
- Last edited
- 21/08/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Sarah Moore
Scientific
Scientific
Disease Control and Vector Biology Unit (DCVBU)
London School of Hygiene and Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
sarah.moore@lshtm.ac.uk |
Study information
Study design | Cluster controlled randomised trial |
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Primary study design | Interventional |
Secondary study design | Randomised controlled trial |
Study setting(s) | Other |
Study type | Treatment |
Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
Scientific title | Low cost repellents for use in rural Africa: a short-term efficacy, effectiveness and perceived benefit survey in Kilombero, Tanzania |
Study acronym | CRPMA |
Study objectives | As Tanzania progresses towards the goals of the Abuja declaration and insecticide-treated bed nets (ITN) coverage becomes almost universal, there is likely to be a selection pressure on malaria mosquitoes to feed outdoors and earlier in the evening when hosts are available. This coupled with changes in lifestyle such as increased access to electricity so people stay awake later means that the relative exposure of the population to infectious mosquito bites is likely to switch to earlier in the evening. A topical insect repellent containing deet can dramatically reduce malaria in South America and Southern Asia where vectors feed early in the evening. The project aims to measure the impact of such a repellent on clinical episodes of malaria in rural Africa. |
Ethics approval(s) | 1. Ifakara Health Institute Institutional Review Board, 10/11/2008, ref: IHRDC/IRB/No. A46 2. National Institute of Medical Research, Tanzania, 06/03/2009, ref: NIMR/HQ/R8a/VolIX/780 |
Health condition(s) or problem(s) studied | Malaria |
Intervention | Long lasting insecticide treated nets (Olyset) + 15% deet repellent Long lasting insecticide treated nets (Olyset) + placebo lotion Total duration of intervention: 44 weeks Total duration of follow-up: 1 month after the trial ends |
Intervention type | Drug |
Pharmaceutical study type(s) | |
Phase | Not Applicable |
Drug / device / biological / vaccine name(s) | Deet-containing insect repellent |
Primary outcome measure | 1. Malaria incidence 2. Clinical episodes of malaria Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial. |
Secondary outcome measures | Malaria prevalence. Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial. |
Overall study start date | 30/08/2009 |
Completion date | 30/07/2010 |
Eligibility
Participant type(s) | Patient |
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Age group | Adult |
Lower age limit | 18 Years |
Sex | Both |
Target number of participants | 4819 |
Key inclusion criteria | Household head over 18 years, either sex |
Key exclusion criteria | Under six months of age |
Date of first enrolment | 30/08/2009 |
Date of final enrolment | 30/07/2010 |
Locations
Countries of recruitment
- England
- Tanzania
- United Kingdom
Study participating centre
Disease Control and Vector Biology Unit (DCVBU)
London
WC1E 7HT
United Kingdom
WC1E 7HT
United Kingdom
Sponsor information
Ifakara Health Institute (Tanzania)
Research organisation
Research organisation
Box 53
Ifakara
53
Tanzania
Website | http://www.ihi.or.tz/ |
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https://ror.org/04js17g72 |
Funders
Funder type
Research organisation
Population Services International (PSI) (Tanzania) - Innovations Grant
No information available
Results and Publications
Intention to publish date | |
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Individual participant data (IPD) Intention to share | No |
IPD sharing plan summary | Not provided at time of registration |
Publication and dissemination plan | Not provided at time of registration |
IPD sharing plan |
Study outputs
Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
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Results article | results | 16/08/2014 | Yes | No |