Growth of skeletal muscle in response to feeding different amounts of protein
| ISRCTN | ISRCTN92528122 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN92528122 |
| Secondary identifying numbers | N/A |
- Submission date
- 13/09/2012
- Registration date
- 01/10/2012
- Last edited
- 15/09/2015
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Musculoskeletal Diseases
Plain English summary of protocol
Background and study aims
Exercise and diet affect the muscles’ ability to make new proteins (muscle protein synthesis). Consuming protein after resistance exercise increases muscle protein synthesis (e.g., for building muscle). However, the best dose of protein to consume is not currently known. If too much protein is consumed, then the excess will be used for energy rather than for building muscle. This information is needed to improve diet and exercise strategies to increase muscle mass not only for healthy young exercisers, but also for helping more vulnerable groups, such as the elderly, to maintain muscle mass. The aim of this study is to determine the response of muscle protein synthesis to different doses of whey protein consumed at rest and following resistance exercise.
Who can participate?
Trained male weightlifters aged between 18-35, who have been doing resistance training for at least 6 months.
What does the study involve?
Participants are randomly allocated to consume one of four doses of whey protein after exercise. Chemical tracers are injected into the bloodstream for delivery to the muscle, and blood and muscle samples are taken to determine the rate at which muscle proteins were made following each dose of protein.
What are the possible health benefits and risks of participating?
The results of this study may help both young and old people who would benefit from muscle growth. The risks of participation include the potential for pain due to the vigorous exercise. However, we used trained experienced weightlifters for this study. Taking a muscle sample may cause pain or discomfort. Injecting the tracers can cause pain or discomfort through infection. However, this is extremely rare.
Where is the study run from?
University of Birmingham (UK).
When is the study starting and how long it is expected to run for?
December 2008 to June 2011.
Who is funding the study?
GlaxoSmithKline Nutritional Healthcare (UK).
Who is the main contact?
Dr Oliver C Witard
oliver.witard@stir.ac.uk
Contact information
Scientific
University of Stirling
School of Sport
Stirling
FK9 4HG
United Kingdom
| Phone | +44 (0)1786 466 298 |
|---|---|
| oliver.witard@stir.ac.uk |
Study information
| Study design | Parallel research design single-blind intervention study |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Other |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | Response of myofibrillar muscle protein synthesis to increasing doses of whey protein at rest and following exercise subsequent to a meal in resistance trained males |
| Study objectives | Twenty grams of whey protein will be sufficient for the maximal stimulation of myofibrillar-muscle protein synthesis (MPS) rates at rest and after resistance exercise in trained, young adult males. |
| Ethics approval(s) | National Research Ethics Service, Black Country, Birmingham, 08/02/2012, ref: 08/H1202/131 |
| Health condition(s) or problem(s) studied | Metabolic health of muscle / sarcopenia (age-related muscle loss) |
| Intervention | Each participant was randomly assigned to one of four groups. Each participant ingested one of four doses (0, 10, 20 or 40g) of whey protein after the exercise. |
| Intervention type | Supplement |
| Primary outcome measure | Myofibrillar (contractile proteins) muscle protein synthesis |
| Secondary outcome measures | Amino acid concentrations |
| Overall study start date | 01/01/2008 |
| Completion date | 01/06/2011 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 35 Years |
| Sex | Male |
| Target number of participants | 48 participants were completed |
| Key inclusion criteria | 1. Male, aged 18-35 years 2. Healthy (no known metabolic disorder) 3. Experienced weight lifter for more than 6 months (at least 2 leg resistance training sessions per week) |
| Key exclusion criteria | Not simultaneously taking part in another scientific / clinical study |
| Date of first enrolment | 01/01/2008 |
| Date of final enrolment | 01/06/2011 |
Locations
Countries of recruitment
- Scotland
- United Kingdom
Study participating centre
FK9 4HG
United Kingdom
Sponsor information
Industry
GSK House
980 Great West Road
Brentford
Middlesex
London
TW8 9GS
United Kingdom
| claire.2.lawrence@gsk.com | |
| Website | http://www.gsk.com/ |
"ROR" |
https://ror.org/01xsqw823 |
Funders
Funder type
Industry
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/01/2014 | Yes | No |
