Condition category
Circulatory System
Date applied
12/11/2004
Date assigned
07/03/2005
Last edited
30/10/2008
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr John Myburgh

ORCID ID

Contact details

Intensive Care Unit
The St George Hospital
Gray Street
Kogarah
Sydney
2217
Australia

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

The Cat study

Study hypothesis

The aim of the Cat study is to compare the clinical effects of adrenaline and noradrenaline in critically ill patients with circulatory dysfunction or failure. It is a prospective, double blind, randomised trial. Patients will be designated a priori into two groups: circulatory failure due to sepsis syndrome/septic shock and circulatory failure due to non-septic causes (cardiogenic shock, normovolaemic hypotension, augmentation of mean arterial pressure). The null hypothesis assumes no difference in resolution of circulatory failure or all-cause mortality in patients with circulatory failure receiving infusions of either adrenaline or noradrenaline.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Condition

Circulatory failure in critically ill patients

Intervention

Patients randomised to receive either adrenaline or noradrenaline

Intervention type

Drug

Phase

Not Specified

Drug names

adrenaline or noradrenaline

Primary outcome measures

Time to resolution of circulatory failure to pre-morbid state from commencement of catecholamine.

Secondary outcome measures

ICU length of stay and mortality, hospital mortality and 90-day mortality: degree of organ dysfunction during 28-day period (as determined by SOFA scores): cardiovascular, respiratory, renal, neurological, hepatic; and metabolic function.

Overall trial start date

01/10/2003

Overall trial end date

31/10/2005

Reason abandoned

Eligibility

Participant inclusion criteria

Critically ill patients requiring a catacholamine infusion for cardiovascular support

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

250

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/10/2003

Recruitment end date

31/10/2005

Locations

Countries of recruitment

Australia

Trial participating centre

Intensive Care Unit
Kogarah, Sydney
2217
Australia

Sponsor information

Organisation

The St George Hospital - Dept of Intensive Care (Australia)

Sponsor details

Gray Street
Kogarah
Sydney
2217
Australia

Sponsor type

Hospital/treatment centre

Website

Funders

Funder type

Not defined

Funder name

Not provided at time of registration

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2008 results on http://www.ncbi.nlm.nih.gov/pubmed/18654759

Publication citations

  1. Results

    Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J, , A comparison of epinephrine and norepinephrine in critically ill patients., Intensive Care Med, 2008, 34, 12, 2226-2234, doi: 10.1007/s00134-008-1219-0.

Additional files

Editorial Notes