Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
The Cat study
Study hypothesis
The aim of the Cat study is to compare the clinical effects of adrenaline and noradrenaline in critically ill patients with circulatory dysfunction or failure. It is a prospective, double blind, randomised trial. Patients will be designated a priori into two groups: circulatory failure due to sepsis syndrome/septic shock and circulatory failure due to non-septic causes (cardiogenic shock, normovolaemic hypotension, augmentation of mean arterial pressure). The null hypothesis assumes no difference in resolution of circulatory failure or all-cause mortality in patients with circulatory failure receiving infusions of either adrenaline or noradrenaline.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Circulatory failure in critically ill patients
Intervention
Patients randomised to receive either adrenaline or noradrenaline
Intervention type
Drug
Phase
Not Specified
Drug names
adrenaline or noradrenaline
Primary outcome measures
Time to resolution of circulatory failure to pre-morbid state from commencement of catecholamine.
Secondary outcome measures
ICU length of stay and mortality, hospital mortality and 90-day mortality: degree of organ dysfunction during 28-day period (as determined by SOFA scores): cardiovascular, respiratory, renal, neurological, hepatic; and metabolic function.
Overall trial start date
01/10/2003
Overall trial end date
31/10/2005
Reason abandoned
Eligibility
Participant inclusion criteria
Critically ill patients requiring a catacholamine infusion for cardiovascular support
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
250
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/10/2003
Recruitment end date
31/10/2005
Locations
Countries of recruitment
Australia
Trial participating centre
Intensive Care Unit
Kogarah, Sydney
2217
Australia
Funders
Funder type
Not defined
Funder name
Not provided at time of registration
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
2008 results on http://www.ncbi.nlm.nih.gov/pubmed/18654759
Publication citations
-
Results
Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J, , A comparison of epinephrine and norepinephrine in critically ill patients., Intensive Care Med, 2008, 34, 12, 2226-2234, doi: 10.1007/s00134-008-1219-0.