MoCog - influence of physical activity and training on motor and cognitive performance in older people [MoKog - Einfluss von körperlich-sportlicher Aktivität und Training auf die motorische und geistige Leistungsfähigkeit bei älteren Personen]
| ISRCTN | ISRCTN94172781 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN94172781 |
| Secondary identifying numbers | N/A |
- Submission date
- 08/12/2008
- Registration date
- 05/02/2009
- Last edited
- 05/02/2009
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nervous System Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Heinz Mechling
Scientific
Scientific
Institute of Sport Gerontology
German Sport University Cologne
Am Sportpark Muengersdorf 6
Cologne
50933
Germany
| Phone | +49 (0)221 4982 6148 |
|---|---|
| mechling@dshs-koeln.de |
Study information
| Study design | Interventional randomised controlled trial nested within a cross-sectional, longitudinal study |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Other |
| Study type | Quality of life |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | MoCog - Intervention study on motor and cognitive performance of older adults with and without Alzheimers disease [MoKog - Eine Interventionsstudie zur körperlichen und geistigen Leistungsfähigkeit bei älteren Personen mit und ohne Alzheimer Demenz] |
| Study acronym | MoCog [MoKog] |
| Study objectives | The aims of the study are: 1. To analyse the differences in motor and cognitive performance between: 1.1. Healthy and demented persons 1.2. Physically active and inactive persons 2. To show whether increased physical activity reduces the progression of Alzheimer's disease 3. To examine the relationship between physical activity across life span and cognitive performance 4. To examine: 4.1. The correlation of motor and cognitive performance 4.2. The influence of Alzheimer's disease on motor performance 4.3. The effect of the genetic risk factor APOE4 on cognitive performance and health-related fitness 5. To improve motor and cognitive performance through exercise training 6. To compare the effectiveness of different exercise programs (endurance and strength training) 7. To evaluate the feasibility and acceptance of the exercise training program |
| Ethics approval(s) | Ethics-Committee of the Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelm University of Bonn, gave approval on the 21st November 2003 (ref: 156/03). Amendment on 23rd January 2006 (ref: 179/03). |
| Health condition(s) or problem(s) studied | Alzheimer's disease |
| Intervention | 1. Intervention group: Participants exercise two times per week for three months. Every session comprises 60 minutes (5 - 10 minute warm-up and 5 - 10 minute cool-down on an ergometer). Participants were divided into either a strength training group or an endurance training group: 1.1. Strength training group: Weight training of the major muscle groups for 60 minutes per session. Starting with strength-endurance and intramuscular coordination training (40 - 60% of one repetition maximum [RM], three sets of 20 repetitions) in the initial starting program (first 4 weeks), followed by hypertrophy training (80% of one RM, three sets of 8 - 12 repetitions) for 8 weeks. The intensity of loading was gradually increased, adapted on subjectively perceived exertion (16 to 18 points on the Borg scale). 1.2. Endurance training group: The endurance training on an ergometer was in accordance with the American College of Sports Medicine's (ACSM's) guidelines for exercise prescription. Volume and intensity of effort were gradually increased every week, starting at 20 minutes and 50 - 60% heart rate (HR) and ending at 60 minutes and 75 - 80% HR max. 2. Control group: The participants of the control group received no intervention. Possible changes in physical activities in the intervention group and control group were controlled by a questionnaire. Total duration of treatment: 24 training sessions Total duration of follow-up: 2 - 5 days Scientific Contact details: Dr Sabine Eichberg Institute of Sport Gerontology German Sport University Cologne Am Sportpark Muengersdorf 6 Cologne 50933 Germany Email: eichberg@dshs-koeln.de |
| Intervention type | Other |
| Primary outcome measure | 1. Health status: genotype testing (Presilin-1-Gen, Presilin-2-Gen, Apolipoprotein E2, 3, 4), measured pre-test only 2. Health-related fitness, measured pre-test and post-test: 2.1. Endurance via ergometer (World Health Organization [WHO] protocol, lactate analysis) 2.2. Maximal isometric strength (knee flexion, knee extension, hip adduction, hip abduction, forearm extension, forearm flexion, hand grip) 2.3. Strength-endurance (chair rising, arm-curl) 2.4. Flexibility (trunk and head rotation, back scratch, sit and reach) 2.5. Reaction and movement time (simple/choice reaction) 2.6. Fine motor movement (hand-eye coordination) 2.7. Balance (Romberg Test with and without visual control, Tandem and Semi-Tandem Stand) 3. Cognitive function, measured pre-test and post-test: 3.1. Cognitive screening (Mini Mental Status Test [MMST]) 3.2. Vocabulary (Multiple-Choice Word Test [MWT-B]) 3.3. Immediate verbal and visual-spatial memory span (Corsi Block Tapping Test) 3.4. Digits forward/backward (Wechsler Adult Intelligence Scale [WAIS]) 3.5. Information processing speed and attention (d2, Trail-Making Test Parts A and B [TMT A/B]) 3.6. Perceptual speed and response inhibition (cerebraler Insutfizienz Test [c.I.Test]) 3.7. Word fluency and mental rotation (Leistungsprufsystem [LPS]) 3.8. Anticipation and planning (Maze Test) 3.9. Verbal learning (Verbaler Lern- und Merkfähigkeitstest [VLMT]) |
| Secondary outcome measures | 1. Health status, measured pre-test and post-test: 1.1. Body composition 1.2. Chronic diseases 1.3. Functional limitations 1.4. Pain 1.5. Rate of falls 1.6. Medication 1.7. Geriatric assessment 1.8. Self-related health (5-point-Likert scale) 1.9. Depression rating scale 1.10. Locus of control 2. Activities, measured pre-test and post-test: 2.1. Leisure time and social activities 2.2. Physical activities (manner, duration, frequency, intensity, last 12 months and across life span) 3. Feedback (from Alzheimer patients and caregiver/family member) on exercise program, measured post-test only |
| Overall study start date | 01/04/2006 |
| Completion date | 13/08/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 240 |
| Key inclusion criteria | 1. Men and women, aged 49 to 93 years 2. Participants must be able to understand, read, and speak German 3. The patients sample is diagnosed with Alzheimer's disease (light or moderate) which was assessed with the Consortium to establish a Registry for Alzheimer's Disease (CERAD) neuropsychological test battery 4. Participants must have an mini-mental state examination (MMSE) score greater than or equal to 10 points 5. Participants without Alzheimer's disease have to be older than 60 years and must have an MMSE score greater than or equal to 24 |
| Key exclusion criteria | 1. Patients with one of the following diseases: 1.1. Acute coronary heart diseases 1.2. Thrombophlebitis 1.3. Acute lung diseases 1.4. Infections 1.5. Osteoporosis 2. Patients who are not able to sit or stand without aid |
| Date of first enrolment | 01/04/2006 |
| Date of final enrolment | 13/08/2007 |
Locations
Countries of recruitment
- Germany
Study participating centre
Institute of Sport Gerontology
Cologne
50933
Germany
50933
Germany
Sponsor information
Institute of Sport Science (Germany)
Research organisation
Research organisation
University of Bonn
Nachtigallenweg 86
Bonn
53127
Germany
| mechling@uni-bonn.de | |
| Website | http://www1.uni-bonn.de/startseite/jsp/index.jsp |
"ROR" |
https://ror.org/041nas322 |
Funders
Funder type
University/education
University of Bonn (Germany)
No information available
German Sport University Cologne (Germany)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
