Finding the Optimal Resistance Training Exercise for type 2 diabetes
| ISRCTN | ISRCTN97865321 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN97865321 |
| Secondary identifying numbers | #19581 |
- Submission date
- 14/01/2010
- Registration date
- 21/06/2010
- Last edited
- 21/06/2010
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nutritional, Metabolic, Endocrine
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English Summary
Not provided at time of registration
Contact information
Dr Paul Oh
Scientific
Scientific
Toronto Rehabilitation Institute
347 Rumsey Rd
Toronto
M4G 1R7
Canada
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Quality of life |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | Finding the optimal volume and intensity of resistance training exercise for type 2 diabetes: a randomised controlled trial |
| Study acronym | The FORTE Study |
| Study hypothesis | A higher intensity, hypertrophic resistance training protocol added to aerobic training would lead to more marked improvements to glycaemic control and cardiovascular risk factors compared to lower intensity endurance training. |
| Ethics approval(s) | University of Toronto Research Ethics Board (REB) approved in February 2006 (ref: 19581) |
| Condition | Type 2 diabetes |
| Intervention | Six months of aerobic and resistance training: 1. Aerobic training and minimal resistance training (usual care) 2. Aerobic training and high intensity resistance training 3. Aerobic training and low intensity resistance training The intervention for all groups was 6 months. Following completion of the program, patients will not be followed-up. |
| Intervention type | Other |
| Primary outcome measure | Measured at baseline and 6 months: 1. HbA1c 2. Maximal aerobic power (VO2 max) |
| Secondary outcome measures | Measured at baseline and 6 months: 1. Fasting glucose 2. Insulin 3. Proinsulin 4. Blood lipid profile 5. Body composition (dual energy x-ray absorptiometry [DEXA]) 6. Cytokines (interleukin-6 [IL-6], interleukin-1B [IL-1B], c-reactive protein [CRP]) 7. Adipokines (tumour necrotising factor-alpha [TNF-alpha], adiponectin, leptin, leptin receptor) 8. Depressive mood (Center for Epidemiologic Studies Depression Scale [CESD]) 9. Quality of life (Diabetes Quality of Life Clinical Trial Questionnaire [DSQLQ]) 10. Nutrition intake |
| Overall study start date | 01/05/2006 |
| Overall study end date | 31/03/2009 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Sex | Both |
| Target number of participants | 120 |
| Participant inclusion criteria | 1. Adults aged greater than 18 years, either sex 2. Type 2 Diabetes 3. Participating in the Diabetes Exercise and Healthy Lifestyle Program of the Toronto Rehabilitation Institute |
| Participant exclusion criteria | 1. History of diagnosed cardiovascular disease 2. Contraindications to high intensity exercise participation: 2.1. Glaucoma 2.2. Retinopathy 2.3. Musculoskeletal limitations 2.4. Kidney disease 2.5. Balance impairments |
| Recruitment start date | 01/05/2006 |
| Recruitment end date | 31/03/2009 |
Locations
Countries of recruitment
- Canada
Study participating centre
Toronto Rehabilitation Institute
Toronto
M4G 1R7
Canada
M4G 1R7
Canada
Sponsor information
Toronto Rehabilitation Institute (Canada)
Research organisation
Research organisation
c/o Paul Oh, MD
347 Rumsey Road
Toronto
M4G 1R7
Canada
| Phone | 1 416 597 3422 |
|---|---|
| oh.pauldr@torontorehab.on.ca | |
| Website | http://www.torontorehab.on.ca/ |
"ROR" |
https://ror.org/00mxe0976 |
Funders
Funder type
Research organisation
Toronto Rehabilitation Institute (Canada)
Private sector organisation / Other non-profit organizations
Private sector organisation / Other non-profit organizations
- Alternative name(s)
- Toronto Rehab, UHN Toronto Rehabilitation Institute, TRI
- Location
- Canada
Human Physiology Performance Laboratory (Canada)
No information available
Canadian Diabetes Association (Canada)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
