Condition category
Circulatory System
Date applied
09/03/2017
Date assigned
17/03/2017
Last edited
16/03/2017
Prospective/Retrospective
Retrospectively registered
Overall trial status
Ongoing
Recruitment status
No longer recruiting

Plain English Summary

Background and study aims
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare disease that affects the heart muscle. It is an inherited condition that is passed on through families. ARVC causes the heart muscle to break down and become replaced with fat and scar tissue. This causes the different chambers of the heart (ventricles) to become thin and stretched making the heart unable to pump blood properly. This causes abnormal heart beats (arrhythmia), heart palpitations (sudden beating), fainting, breathlessness, and even carries a risk of sudden death. Cardiovascular magnetic resonance imaging (CMR) (a scan that uses magnetic fields and radio waves to make a detailed image of the heart) is considered the best way for measuring right ventricular (RV) volume due to its ability to see the entire RV. However, measuring how well the RV functions (works) is based on seeing and scoring the wall motion which can be subjective. Recent research has developed new models for measuring RV such as using speckle-tracking. This is an established technique that is used to measure tissue velocity (speed and direction) and deformation (strain) using the natural speckle pattern in heart muscle during a scan. The method has been adapted into the CMR and is promoted as “feature tracking” which can be applied to measuring the left ventricular walls. However, as the heart changes due to ARVC and the challenges using software to track the changes, there is question if this new method is able to accurately predict ARVC. The aim of this study is to analyse the RV function using CMR-feature tracking in patients with ARVC to see if it could detect changes in wall deformation (strain) and beating which could then predict the occurrence of arrhythmia in these patients.

Who can participate?
Adults who are diagnosed with ARVC and healthy participants with no family history of early heart disease.

What does the study involve?
All participants undergo a CMR with feature tracking. This includes a full body scan for 30-40 minutes. Participants with ARVC also undergo non-invasive tests that records how well their hearts are working. The images from the CMR are compared between participants with ARVC and health controls to see how well the CMR with featured tracking is able to differentiate between these two groups. Those with ARVC also undergo more non-invasive heart tests. Participants with ARVC are followed with yearly outpatient visits for five years and undergo heart tests if required. Healthy participants have no planned follow up.

What are the possible benefits and risks of participating?
Participants may benefit from having their health checked and given health care advice. There are no notable risks with participating.

Where is the study run from?
University Hospital Linköping (Sweden)

When is the study starting and how long is it expected to run for?
December 2008 to December 2017

Who is funding the study?
Swedish Heart-Lung Foundation (Sweden)

Who is the main contact?
Dr Meriam Åström Aneq

Trial website

Contact information

Type

Scientific

Primary contact

Dr Meriam Åström Aneq

ORCID ID

Contact details

Linköping University Hospital
Institute of Medicine and Health Care
Department of Clinical Physiology
Universitetssjukhuset
Linköping
58185
Sweden

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

ARVC och plötslig hjärtdöd

Study information

Scientific title

Quantitative CMR analysis of right ventricular function and synchronicity in patients with arrhythmogenic right ventricular cardiomyopathy: Could this be predictive of arrhythmias

Acronym

Study hypothesis

The detection of changes in wall deformation and synchronicity in the right ventricle (RV) could indicate a propensity for arrhythmia in arrhythmogenic right ventricular cardiomyopathy ARVC.

Ethics approval

The Regional Ethical Review Board in Linköping, 29/04/2009, ref: M68-09/2009

Study design

Observational cross-sectional cohort study

Primary study design

Observational

Secondary study design

Cross sectional study

Trial setting

Hospitals

Trial type

Diagnostic

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet

Condition

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Intervention

Participants (both healthy controls and those with ARVC) undergo a cardiac magnetic resonance imaging (CMR). This is done for participants as part of their clinical workup for an ARVC diagnosis (according to the international Task Force Criteria). A new acquisition model based on rotated slices has been added to the standard clinical CMR testing and this requires participants to be scanned for an extra ten minutes. The entire CMR investigation takes around 30-40 minutes. CMR images are then evaluated by analysing wall deformation, called “Feature Tracking”.

In addition, participants with ARCV undergo non-invasive testing. This includes an electrocardiogram (ECG), echocardiogram and a 24 hour ECG. These tests are part of the standard clinical evaluation for ARVC patients.

Images from the CMR are analysed and compared to the control group to see how well the CMR is at differentiating between healthy patients and those with ARVC.

No further follow-up is planned for the healthy control group.

Participants with ARVC are followed up with yearly outpatient visits for symptoms of arrhythmia. Holter monitors and echocardiograms are ordered every 2-3 years (or according to the need). In the case that the patient has an ICD implant, the arrhythmia event recorded is evaluated after any clinical events or at the outpatient visits.

Intervention type

Device

Phase

Drug names

Primary outcome measures

1. Strain values are measured using Feature tracking method once with clinically indicated CMR with additional acquisition model at baseline
2. Time to peak strain is measured using the Feature tracking method with clinically indicated CMR with additional acquisition model at baseline

Secondary outcome measures

Arrhythmia relation to strain values are measuring using the CMR examination with additional acquisition and the yearly interrogation of ICDs and available Holter recordings at year one, two, three, four and five (or when clinically necessary)

Overall trial start date

01/12/2008

Overall trial end date

31/12/2017

Reason abandoned

Eligibility

Participant inclusion criteria

Patients:
1. Diagnosis of a definite ARVC
2. Have not received an implantable cardioverter defibrillator (ICD)
3. Aged 18 years and older

Healthy Participants:
1. Age matched asymptomatic who lack a family history of premature cardiovascular disease
2. Not on cardiac medication
3. Pass a cardiac exercise test
4. Aged 18 years and older

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

All ARVC patients at Linköping University hospital, and without an ICD are included

Participant exclusion criteria

The presence of an implantable cardioverter defibrillator (ICD).

Recruitment start date

30/10/2009

Recruitment end date

30/12/2014

Locations

Countries of recruitment

Sweden

Trial participating centre

University Hospital Linköping
Universitetssjukhuset
Linköping
58185
Sweden

Sponsor information

Organisation

Linköping University Hospital

Sponsor details

Institute of Medicine and Health Care
Department of Clinical Physiology
Universitetssjukhuset
Linköping
581 85
Sweden

Sponsor type

Hospital/treatment centre

Website

Funders

Funder type

Charity

Funder name

Swedish Heart-Lung Foundation (Hjärt-Lungfonden)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Presentation of preliminary study results as a poster abstract was done in 2014 at Euro-CMR.
Publication in peer review journal is planned as soon as the manuscript is finalised.

IPD sharing plan:
The datasets generated during and/or analysed during the current study are/will be available upon request from Meriam Åström Aneq meriam.astrom.aneq@regionostergotland.se

Intention to publish date

15/08/2017

Participant level data

Available on request

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes