Plain English Summary
Background and study aims
Lower eyelid involutional entropion causes the eyelid margin and eyelashes to rotate inward and irritate the eye. It usually occurs in individuals above 50 years of age. Many surgical methods have been designed to correct the contributing factors, but even so, recurrence is still a troublesome complication. To reduce the risk for recurrence, surgeons have modified the procedures according to the patients. The type of surgical procedure to be adopted should also be determined according to racial anatomical differences. Therefore, researchers have proposed a new surgical method modified from the Quickert procedure. This surgical design can cover most of the triggering causes in Asians. The aim of this study is to review the outcomes of patients who have undergone this surgery during the past five years (from January 2012 to October 2017).
Who can participate?
Patients aged over 55 years who had been diagnosed with involutional entropion and underwent the new surgical technique for repair
What does the study involve?
Information is collected from each patient’s medical record including surgical success, complications and recurrence. All surgical procedures and examinations are performed by a single oculoplastic surgeon (CY Chen) using consistent techniques.
What are the possible benefits and risks of participating?
The surgical procedure was modified from the Quickert procedure in some steps, and the Quickert procedure has been well confirmed in the correction of lower lid entropion. The modified surgical procedure is thought to be safe and effective, and result in less recurrence, overcorrection and complication.
Where is the study run from?
Chang Gung Memorial Hospital (Taiwan)
When is the study starting and how long is it expected to run for?
July 2018 to January 2019
Who is funding the study?
Chang Gung Memorial Hospital (Taiwan)
Who is the main contact?
Mr Chauyin Chen
Chia Pu Road
Pu Zih City
Using a modified Quickert procedure combined with prolapsed fat removal to correct involutional lower eyelid entropion in Asians
The researchers propose a new surgical method modified from Quickert procedure. This surgical design can cover most of the triggering causes in Asians.
Approved 04/07/2018, Chang Gung Medical Foundation Institutional Review Board (199, Tung Hwa North Road, Taipei, Taiwan, 10507, Republic Of China; +886 (0)3 3196200; email@example.com), IRB No.: 201801039B0
Retrospective observational cross-sectional cohort study
Primary study design
Secondary study design
Cross sectional study
Patient information sheet
Not available in web format, please use contact details to request a participant information sheet
Involutional lower eyelid entropion
Every outpatient receiving the modified Quickert procedure is arranged regular follow-ups at the outpatient clinic at the time of pre-op, 1 week and 2 months after surgery, and then when needed according to the patient's other chronic eye diseases.
Primary outcome measure
Success rate: successful surgery was defined as a normal eyelid position at rest, and inability to induce entropion by provocative test. Success rate was measured using external eye photography and provocative test performed in clinic, measured at follow-up after 2 months, and also after 12 months for patients when needed due to their other ocular diseases
Secondary outcome measures
Measured at follow-up after 2 months, and also after 12 months for patients when needed due to their other ocular diseases:
1. Recurrence rate: recurrence defined as either the majority of eyelashes remained in contact with the globe or persistent irritation/keratitis in the presence of residual in-turned eyelashes
2. Overcorrection rate: overcorrection defined as ectropion and conjunctiva inside out
3. Complication rate: complication defined as formation of symblepharon, wound infection or wound dehiscence during the follow-up period
Overall trial start date
Overall trial end date
Reason abandoned (if study stopped)
Participant inclusion criteria
1. Patients aged > 55 years
2. Involutional lower eyelid entropion confirmed by the presenting of trichiasis, eyelid laxity, vertical laxity, and abundant of orbicularis
Target number of participants
Total final enrolment
Participant exclusion criteria
1. Patients with concurrent eyelid pathologies such as malignant tumor, cicatricial entropion caused by trauma, infection or inflammatory, spastic entropion caused by essential blepharospasm, hemifacial spasm-involutional entropion
2. Post-operative follow-up period of < 2 months
3. Aged < 55 years at the time of surgery
4. Patients with any history of previous surgery for involutional entropion
Recruitment start date
Recruitment end date
Countries of recruitment
Trial participating centre
Chang Gung Memorial Hospital
Department of Ophthalmology 6, Sec, West, Chia Pu Road, Pu Zih City
Chiayi Chang Gung Memorial Hospital
Chia-Yi Chang-Gong Memorial Hospital, Chang Gung Memorial Hospital, Chia-Yi
Funding Body Type
private sector organisation
Funding Body Subtype
Other non-profit organizations
Results and Publications
Publication and dissemination plan
Planned publication in an ophthamology or plastic surgery journal
IPD sharing statement
The datasets generated and/or analyzed during the current study during this study will be included in the subsequent results publication.
Intention to publish date
Participant level data
Basic results (scientific)
See additional files
- ISRCTN39804797_BasicResults_29Apr20.pdf uploaded 18/05/2020