A Prospective, Randomised, Double-blind, Placebo Controlled Study to assess the Role of Aloe Vera with or without Glucosamine & Chondroitin in Patients with Symptomatic Osteoarthritis of Knees

ISRCTN	ISRCTN01562001
DOI	https://doi.org/10.1186/ISRCTN01562001
Protocol serial number	N0020180355
Sponsor	Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Funder	Barking, Havering and Redbridge Hospitals NHS Trust (UK)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Prof Kuntal Chakravarty
Scientific

Consultant Rheumatologist
Rheumatology Department
Harold Wood Hospital
Gubbins Lane
Romford
RM3 0BE
United Kingdom

Primary study design	Interventional
Study design	Randomised double-blind placebo-controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	A Prospective, Randomised, Double-blind, Placebo Controlled Study to assess the Role of Aloe Vera with or without Glucosamine & Chondroitin in Patients with Symptomatic Osteoarthritis of Knees
Study objectives	To evaluate the role of aloe vera with or without glucosamine and Chondroitin in patients with symptomatic osteoarthritis of knees.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Musculoskeletal Diseases: Osteoarthritis of the knee
Intervention	Aloe vera with or without glucosamine and Chondroitin
Intervention type	Drug
Phase	Not Applicable
Drug / device / biological / vaccine name(s)	Aloe vera with or without glucosamine and Chondroitin
Primary outcome measure(s)	1. Assessment and comparison of overall symptoms including pain, range of motions and variables such as swelling etc in the affected joints and other measures of functional aspects of the joint 2. Assessment of Quality of life
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	30/04/2008

Participant type(s)	Patient
Age group	Adult
Lower age limit	18 Years
Sex	Not Specified
Key inclusion criteria	1. Age between 18 - 80 years 2. Symptoms of episodic or continuous pain in the affected knee joint for 6 weeks 3. Diagnosis of OA of Knee made according to ACR criteria (knee pain and radiographic osteophytes and at least any one of the following 3 items: a) Age > 50 years b) Morning Stiffness < 30 minutes in duration c) Crepitus on motion
Key exclusion criteria	1. Any contra indication to Aloe Vera /Glucosamine/Chondroitin 2. Current Use or use within 3 months of screening of aloe vera/Glucosamine/Chondroitin 3. Current or Previous history of oral steroid or injection in the study joint within 3 months 4.Current or previous history of Intra articular Synvisc or Hyalgan therapy 5. Previous history of NSAID topical application within the last 3 months 6. Any previous history of Knee surgery including Menisectomy / patellectomy etc 7. Presence of Inflammatory Arthritis 8. Presence of significant hip disease on the side of symptomatic knee
Date of first enrolment	01/04/2006
Date of final enrolment	30/04/2008

Harold Wood Hospital

Romford
RM3 0BE
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes