Resources

Quick links

What are clinical trials?

Guidelines for study registration and reporting

Other public registries and portals

Legislation around clinical trials

ISRCTN works with a number of stakeholders to improve the information publicly available about clinical trials.

ISRCTN supports open access to clinical trial data information in line with:

  • World Health Organization guidelines - registration of all interventional trials is considered to be a scientific, ethical and moral responsibility.
  • ICMJE statements - for a manuscript to be considered, trial details should be deposited before recruitment starts.
  • Industry recommendations - trial information should be deposited within 21 days of recruitment starting and results be made available within one year of market authorisation.

ISRCTN helps ensure that a number of organisations meet their trial registration objectives:

ISRCTN works to streamline trial registration processes with the following organisations:

  • The National Institute for Health Research through the NIHR Central Portfolio Management System (CPMS) - adoption by the Portfolio ensures that trials can benefit from NHS support and the Portfolio sends trial data batches on behalf of researchers who have opted for ISRCTN registration.
  • The Health Research Authority and its partners through the Integrated Research Application System - IRAS is a centralised system that helps researchers apply for permissions and approvals for health and social care research in the UK.

ISRCTN engages with the following organisations to make sure that current and future participants are better informed about relevant trials:

ISRCTN maximises the visibility of its clinical trial data by feeding it to other web platforms:

  • WHO clinical trial search portal - ISRCTN data uploaded weekly.
  • Be Part of Research - ISRCTN data uploaded weekly. Be Part of Research aims to list trials that have recruited and are recruiting in the UK and help the UK Government meet its commitment in the NHS Constitution that patients should be made aware of research relevant to them.

ISRCTN follows the development of all publicly available trial registries through its participation in the WHO Working Group on Best Practice for Clinical Trials Registers, in particular: