ISRCTN registry
New UK clinical trials transparency requirements in force from 28 April 2026
Updated regulations introduce new requirements for the registration and reporting of UK clinical trials involving medicines.
What is now required?
Clinical trials involving medicines must:
- Be registered in a public registry
- Publish a summary of results within 12 months of completion
- Offer participants a clear, accessible summary of results
ISRCTN’s role in supporting transparency in clinical research
ISRCTN is the UK’s only WHO-recognised primary clinical study registry, supporting sponsors and researchers in meeting regulatory transparency expectations.
Registering your study
Study registration is straightforward using ISRCTN’s online submission form, with guidance and editorial support available throughout the process.
Download a sample of the submission form
Read guidance on registration
Register a study
Sharing study results
A new online results reporting system will be available soon.
In the meantime, summary results and lay summaries can be uploaded as PDF documents.
Upload results
Read guidance on reporting results
Preview a demo of the new results reporting system
The ISRCTN registry is a primary clinical study registry recognised by the World Health Organisation (WHO) and the International Committee of Medical Journal Editors (ICMJE) that accepts all clinical research studies (whether proposed, ongoing or completed), providing content validation and curation and the unique identification number necessary for publication. All study records in the database are freely accessible and searchable.
ISRCTN supports transparency in clinical research, helps reduce selective reporting of results and ensures an unbiased and complete evidence base.
The registry aims to include all interventional and non-interventional clinical studies that prospectively involve UK participants and evaluate biomedical or health-related outcomes.
Studies conducted outside the UK or considered to be non-clinical studies (e.g. public health studies) can be registered on ISRCTN.
Studies should ideally be registered prospectively (before recruitment starts). ISRCTN also accepts studies registered retrospectively once they are underway or after completion.
Collaborators
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