Omega 3 fatty acids in skin cell protection from ultraviolet damage
| ISRCTN | ISRCTN04778461 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN04778461 |
| Secondary identifying numbers | 4953 |
- Submission date
- 29/04/2010
- Registration date
- 29/04/2010
- Last edited
- 12/04/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Skin and Connective Tissue Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Miss Suzanne Pilkington
Scientific
Scientific
Photobiology Unit
Dermatological Sciences
Hope Hospital
Stott Lane
Salford
M6 8HD
United Kingdom
Study information
| Study design | Non-randomised interventional trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Non randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Not Specified |
| Scientific title | Omega 3 fatty acids in skin cell protection from ultraviolet damage |
| Study objectives | Examination into the photoprotective potential of topically applied omega-3 fatty acids. Changes in the parameters of short- and long-term UV-damage will be assessed. This includes analysis of the sunburn response, bioavailability of fatty acids, expression of lipid mediators and expression of p53 and collagen. |
| Ethics approval(s) | MREC approved, ref: 08/H1004/19 |
| Health condition(s) or problem(s) studied | Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology |
| Intervention | Topical agents containing low doses of omega-3 fatty acids applied to the skin |
| Intervention type | Other |
| Primary outcome measure | To measure changes in the erythemal response to UVR in the skin |
| Secondary outcome measures | 1. To measure changes in levels of bioactive mediators derived from fatty acids in the skin in response 2. To measure changes in the fatty acid levels in the skin |
| Overall study start date | 01/04/2008 |
| Completion date | 30/09/2011 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | Planned Sample Size: 64 |
| Key inclusion criteria | 1. White Caucasian, either sex 2. Aged between 20 and 60 years old 3. Skin type 1 to 3 |
| Key exclusion criteria | 1. Taking photoactive or anti-inflammatory medication 2. History of photosensitivity 3. History of skin cancer 4. Pregnant or breast feeding 5. Taking omega-3 supplements 6. Sunbathed in past 3 months |
| Date of first enrolment | 01/04/2008 |
| Date of final enrolment | 30/09/2011 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Photobiology Unit
Salford
M6 8HD
United Kingdom
M6 8HD
United Kingdom
Sponsor information
University of Manchester (UK)
University/education
University/education
Oxford Road
Manchester
M13 9PL
England
United Kingdom
| Website | http://www.manchester.ac.uk/ |
|---|---|
"ROR" |
https://ror.org/027m9bs27 |
Funders
Funder type
Research council
Biotechnology and Biological Science Research Council (BBSRC) (UK)
No information available
Croda International Plc (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
12/04/2017: No publications found in PubMed, verifying study status with principal investigator.
