Omega 3 fatty acids in skin cell protection from ultraviolet damage
| ISRCTN | ISRCTN04778461 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN04778461 |
| Protocol serial number | 4953 |
| Sponsor | University of Manchester (UK) |
| Funders | Biotechnology and Biological Science Research Council (BBSRC) (UK), Croda International Plc (UK) |
- Submission date
- 29/04/2010
- Registration date
- 29/04/2010
- Last edited
- 12/04/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Skin and Connective Tissue Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Miss Suzanne Pilkington
Scientific
Scientific
Photobiology Unit
Dermatological Sciences
Hope Hospital
Stott Lane
Salford
M6 8HD
United Kingdom
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Non-randomised interventional trial |
| Secondary study design | Non randomised controlled trial |
| Scientific title | Omega 3 fatty acids in skin cell protection from ultraviolet damage |
| Study objectives | Examination into the photoprotective potential of topically applied omega-3 fatty acids. Changes in the parameters of short- and long-term UV-damage will be assessed. This includes analysis of the sunburn response, bioavailability of fatty acids, expression of lipid mediators and expression of p53 and collagen. |
| Ethics approval(s) | MREC approved, ref: 08/H1004/19 |
| Health condition(s) or problem(s) studied | Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology |
| Intervention | Topical agents containing low doses of omega-3 fatty acids applied to the skin |
| Intervention type | Other |
| Primary outcome measure(s) |
To measure changes in the erythemal response to UVR in the skin |
| Key secondary outcome measure(s) |
1. To measure changes in levels of bioactive mediators derived from fatty acids in the skin in response |
| Completion date | 30/09/2011 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 64 |
| Key inclusion criteria | 1. White Caucasian, either sex 2. Aged between 20 and 60 years old 3. Skin type 1 to 3 |
| Key exclusion criteria | 1. Taking photoactive or anti-inflammatory medication 2. History of photosensitivity 3. History of skin cancer 4. Pregnant or breast feeding 5. Taking omega-3 supplements 6. Sunbathed in past 3 months |
| Date of first enrolment | 01/04/2008 |
| Date of final enrolment | 30/09/2011 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Photobiology Unit
Salford
M6 8HD
United Kingdom
M6 8HD
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
12/04/2017: No publications found in PubMed, verifying study status with principal investigator.
