Entomological research, training and prevention strategies for malaria in Africa
| ISRCTN | ISRCTN07404145 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN07404145 |
| Secondary identifying numbers | FSP project 2006-22 |
- Submission date
- 18/04/2012
- Registration date
- 30/04/2012
- Last edited
- 24/04/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Plain English summary of protocol
Background and study aims
Malaria is a serious tropical disease caused by a type of parasite known as Plasmodium that is spread by mosquitoes. Malaria can be prevented by sleeping under a mosquito net treated with insecticide (long lasting insecticidal mosquito nets [LLINs]), by applying insecticide to the inside of dwellings (indoor residual spraying [IRS]), or by covering the walls with plastic sheeting treated with carbamate insecticide (CTPS). However, efforts to control and eliminate malaria in Africa are being challenged by parasites becoming resistant to antimalarial drugs and mosquitoes becoming resistant to insecticides. The aim of this study is to find out whether combinations of LLINs and IRS or an IRS-like treatment (CTPS) are more effective at protecting against malaria than LLINs alone.
Who can participate?
Children aged 0-71 months living in the 28 selected villages
What does the study involve?
Participants are randomly allocated to use one of four malaria prevention strategies:
1. LLINs for pregnant women and children aged under 6
2. LLINs to cover all sleeping units
3. LLINs for pregnant women and children aged under 6 and full coverage with carbamate-IRS
4. LLINs to cover all sleeping units and full coverage with CTPS
Malaria infection rates are compared between the four groups.
What are the possible benefits and risks of participating?
Using a combination of LLINs and IRS could be more effective at reducing malaria-related illness.
Where is the study run from?
The health district of Ouidah-Kpomassè-Tori Bossito (OKT) (Benin)
When is the study starting and how long is it expected to run for?
July 2008 to December 2009
Who is funding the study?
1. Ministry of Foreign and European Affairs (France)
2. Institute of Development Research [Institut de Recherche pour le Développement] (France)
3. The President’s Malaria Initiative (PMI) (USA)
Who is the main contact?
Dr Vincent Corbel
Contact information
Scientific
Institut de Recherche pour le Développement/Centre de Recherche Entomologique de Cotonou (IRD/CREC)
Quartier les cocotiers
Près de la direction générale des impôts
01 BP 4414 RP
Cotonou
00229
Benin
Study information
| Study design | Cluster randomized controlled trial with 18 months follow-up |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Cluster randomised trial |
| Study setting(s) | Home |
| Study type | Prevention |
| Participant information sheet | Not available in web format, please contact Georgia Bakiri (barikiss2000@yahoo.fr) to request a patient information sheet |
| Scientific title | Combining vector control interventions for malaria control in pyrethroid resistance area: a cluster randomized controlled trial in Benin, West Africa |
| Study objectives | The combination of long lasting insecticidal mosquito nets (LLIN) and indoor residual spraying (IRS) or an IRS-like treatment (i.e. carbamate treated plastic sheeting, CTPS) confer protection against malaria and better management of pyrethroid-resistance in vectors than LLIN alone. |
| Ethics approval(s) | National Ethical Committee for Medical Research (CNPERS), Benin, 16/12/2010 |
| Health condition(s) or problem(s) studied | Malaria prevention by vector control strategies |
| Intervention | Four malaria vector control interventions were evaluated as follows: 1. LLIN-targeted coverage [TLLIN] to pregnant women and children <6 years that served as a control group 2. LLIN-universal coverage of all sleeping units [ULLIN] 3. LLIN-targeted coverage to pregnant women and children <6 plus full coverage of Carbamate-IRS [TLLIN+IRS] 4. LLIN-universal coverage of sleeping units plus full coverage of CTPS lined up to the walls of the household [ULLIN+CTPS] |
| Intervention type | Other |
| Primary outcome measure | Incidence density rates of Plasmodium falciparum clinical malaria in children aged under 6 years |
| Secondary outcome measures | 1. The prevalence and parasite density of asymptomatic infections among children aged under 6 years 2. The entomological inoculation rates [(EIR), as defined by the number of infected bites per human per year] 3. The human biting rates [(HBR), as defined by the number of bites per human per year] 4. The prevalence of pyrethroid resistant 1014F kdr allele in malaria vectors |
| Overall study start date | 09/07/2008 |
| Completion date | 23/12/2009 |
Eligibility
| Participant type(s) | Other |
|---|---|
| Age group | Child |
| Lower age limit | 0 Months |
| Upper age limit | 71 Months |
| Sex | Both |
| Target number of participants | 4 arms of 7 villages each with overall 1126 children aged 0-71 months |
| Key inclusion criteria | 1. Children aged 0-71 months 2. Lives in villages selected for study |
| Key exclusion criteria | 1. Inhabitants older than 6 years 2. Children not living in selected villages |
| Date of first enrolment | 09/07/2008 |
| Date of final enrolment | 23/12/2009 |
Locations
Countries of recruitment
- Benin
Study participating centre
00229
Benin
Sponsor information
Government
Centre de Recherche Entomologique de Cotonou (CREC)
Quartier les cocotiers
Près de la direction générale des impôts
01 BP 4414 RP
Cotonou
00229
Benin
| Website | http://en.ird.fr/ |
|---|---|
"ROR" |
https://ror.org/032qezt74 |
Funders
Funder type
Government
No information available
No information available
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/08/2012 | Yes | No |
Editorial Notes
24/04/2017: Plain English summary added.
