The contribution of race as a determining factor in the development of glaucoma
| ISRCTN | ISRCTN09311359 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN09311359 |
| Protocol serial number | N/A |
| Sponsor | Guy's and St. Thomas NHS Foundation Trust (UK) |
| Funder | Eye Hope Charity (UK) |
- Submission date
- 07/12/2009
- Registration date
- 02/02/2010
- Last edited
- 11/07/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Eye Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Mr Kin Sheng Lim
Scientific
Scientific
St. Thomas' Hospital
Westminster Bridge Road
London
SE1 7EH
United Kingdom
| Phone | +44 (0)20 7188 2289 |
|---|---|
| shenglim@gmail.com |
Study information
| Primary study design | Observational |
|---|---|
| Study design | Prospective observational longitudinal non-randomised study |
| Secondary study design | Non randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | The contribution of race as a determining factor in the development of Primary Open Angle Glaucoma (POAG): An observational trial |
| Study acronym | ADS (aqueous dynamic study) |
| Study objectives | The distribution of aqueous production rate and the out-flow facility in patients from different racial groups with POAG. Primary open angle glaucoma is defined as glaucomatous optic neuropathy together with an IOP >21 mmHg on at least one occasion and visual field defects (using the 24-2 test pattern on a Humphrey Field Analyzer) and a gonioscopic angle width of 3 or 4 and normal in appearance. |
| Ethics approval(s) | St. Thomas' Hospital Research Ethics Committee, Approved on 14 August 2007, REC ref number: 07/Q0702/61 |
| Health condition(s) or problem(s) studied | Primary open angle glaucoma (POAG) |
| Intervention | Patients will receive standard treatment and care. Therefore, there is no intervention, just some extra measurements which used to be part of routine clinical examinations. Additional measurements will be carried out using pnuematonometry, fluorophotometry and Schiotz tonography machines |
| Intervention type | Other |
| Primary outcome measure(s) |
Outflow facility determined |
| Key secondary outcome measure(s) |
1. Anterior chamber depth |
| Completion date | 31/05/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Other |
| Sex | All |
| Target sample size at registration | 60 |
| Key inclusion criteria | 1. Males or Females between ages 18 and 90 2. Availability to participate in all aspects of the study 3. Willingness to participate in a study 4. Ability to undergo accurate fluorophotometry and tonography |
| Key exclusion criteria | 1. History of intraocular surgery or keratorefractive surgery 2. Systemic medications which affects aqueous production, such as beta adrenergic blockers, steroids 3. Fluorescein allergy |
| Date of first enrolment | 15/10/2007 |
| Date of final enrolment | 31/05/2010 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
St. Thomas' Hospital
London
SE1 7EH
United Kingdom
SE1 7EH
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 09/12/2011 | Yes | No | |
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
