Identification of gene markers associated with prognosis for patients with prostate cancer
| ISRCTN | ISRCTN11560295 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN11560295 |
- Submission date
- 30/11/2021
- Registration date
- 01/12/2021
- Last edited
- 21/01/2025
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Cancer
Plain English summary of protocol
Background and study aims
Prostate cancer is a public health priority in men and the impact of this disease will be more pronounced with the aging of the world’s population. The aim of this study is to identify gene markers associated with the prognosis of prostate cancer to guide clinical practice.
Who can participate?
Patients with prostate cancer in The Cancer Genome Atlas Program (TCGA) and Gene Expression Omnibus (GEO) databases.
What does the study involve?
The researchers will obtain data on prostate cancer from public databases to identify genes related to the prognosis of prostate cancer.
What are the possible benefits and risks of participating?
There are no expected benefits or risks for the participants.
Where is the study run from?
Sichuan University (China)
When is the study starting and how long is it expected to run for?
November 2021 to December 2021
Who is funding the study?
1. National Natural Science Foundation of China (China)
2. Science and Technology Department of Sichuan Province (China)
3. Sichuan University (China)
4. Chengdu Science and Technology Bureau (China)
5. West China Hospital, Sichuan University (China)
Who is the main contact?
Prof. Lu Yang
wycleflue@163.com
Contact information
Scientific
Department of Urology
Institute of Urology
West China Hospital
Sichuan University
Guoxue Xiang #37
Chengdu
610041
China
| Phone | +86 17781480258 |
|---|---|
| wycleflue@163.com |
Study information
| Study design | Retrospective observational study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cross sectional study |
| Study setting(s) | Other |
| Study type | Other |
| Participant information sheet | Not applicable (retrospective study) |
| Scientific title | Prognostic biomarkers in prostate cancer identified through bioinformatic analysis |
| Study acronym | PBPCBA |
| Study objectives | The prognosis of prostate cancer can be predicted by gene markers. |
| Ethics approval(s) | All data is derived from public databases, such as The Cancer Genome Atlas Program (TCGA) and Gene Expression Omnibus (GEO) databases. Thus, ethics approval is not required. |
| Health condition(s) or problem(s) studied | Prognostic markers of prostate cancer |
| Intervention | The Genematrix and clinical data of prostate cancer patients are extracted from the TCGA and GEO databases to compare tumor and normal tissue samples. Univariate and multivariate COX regression analysis is conducted to identify independent factors associated with biochemical recurrence and metastasis. |
| Intervention type | Other |
| Primary outcome measure | Genes associated with biochemical recurrence, identified through bioinformatic analysis of data obtained from the TCGA and GEO database from 01/12/2021 to 05/12/2021 |
| Secondary outcome measures | There are no secondary outcome measures |
| Overall study start date | 30/11/2021 |
| Completion date | 10/12/2021 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Male |
| Target number of participants | 1000 |
| Total final enrolment | 3000 |
| Key inclusion criteria | Patients with prostate cancer in the TCGA and GEO databases |
| Key exclusion criteria | Patients without prognostic information in the TCGA and GEO databases |
| Date of first enrolment | 01/12/2021 |
| Date of final enrolment | 05/12/2021 |
Locations
Countries of recruitment
- China
Study participating centre
Chengdu
610041
China
Sponsor information
University/education
Guoxue Xiang #37
Chengdu
610041
China
| Phone | +86 (0)28 85422451 |
|---|---|
| fdcfenix@stu.scu.edu.cn | |
| Website | https://www.scu.edu.cn/ |
"ROR" |
https://ror.org/011ashp19 |
Funders
Funder type
Hospital/treatment centre
Private sector organisation / Other non-profit organizations
- Alternative name(s)
- West China Hospital, West China School of Medicine and West China Hospital, Sichuan University, WCH, WCSM/WCH
- Location
- China
Government organisation / National government
- Alternative name(s)
- Chinese National Science Foundation, Natural Science Foundation of China, National Science Foundation of China, NNSF of China, NSF of China, 国家自然科学基金委员会, National Nature Science Foundation of China, Guójiā Zìrán Kēxué Jījīn Wěiyuánhuì, NSFC, NNSF, NNSFC
- Location
- China
Government organisation / Local government
- Alternative name(s)
- Sichuan Provincial Department of Science and Technology, Department of Science and Technology of Sichuan Province, Science & Technology Department of Sichuan Province, 四川省科学技术厅, SPDST
- Location
- China
Government organisation / Universities (academic only)
- Alternative name(s)
- 四川大学, 四川大學, Sichuan Union University, SCU
- Location
- China
Government organisation / Local government
- Location
- China
Results and Publications
| Intention to publish date | 20/04/2022 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Other |
| Publication and dissemination plan | Planned publication in a high-impact peer-reviewed journal |
| IPD sharing plan | All data is derived from the public database online, thus the IPD sharing statement is not applicable. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | 29/09/2022 | 06/01/2023 | Yes | No | |
| Results article | 24/02/2022 | 06/01/2023 | Yes | No | |
| Results article | 15/09/2022 | 06/01/2023 | Yes | No | |
| Results article | 06/04/2022 | 06/01/2023 | Yes | No | |
| Results article | 15/09/2022 | 06/01/2023 | Yes | No | |
| Results article | 03/06/2022 | 06/01/2023 | Yes | No | |
| Results article | 12/01/2022 | 06/01/2023 | Yes | No | |
| Results article | 01/03/2023 | 21/01/2025 | Yes | No | |
| Results article | 01/03/2023 | 21/01/2025 | Yes | No |
Editorial Notes
21/01/2025: Publication references added.
06/01/2023: Publication references added.
09/12/2021: Total final enrolment added.
01/12/2021: Trial's existence confirmed by the West China Hospital of Sichuan University Biomedical Research Ethics Committee.
