Evaluating the diagnostic performance of RIPASA and Alvarado scores in acute appendicitis
| ISRCTN | ISRCTN12095411 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN12095411 |
- Submission date
- 21/05/2024
- Registration date
- 29/05/2024
- Last edited
- 29/05/2024
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Digestive System
Plain English summary of protocol
Background and study aims
Appendicitis is an inflammation of the appendix. This study aims to determine which scoring system is better at diagnosing appendicitis.
Who can participate?
All patients presenting to the surgical emergency department with a complaint of severe abdominal pain during the study period
What does the study involve?
The study involved comparing scoring systems to determine the superior one. Patient data was collected through medical history and clinical examination, in addition to conducting laboratory and radiological investigations.
What are the possible benefits and risks of participating?
There is no risk to any of the participants in this study.
Where is the study run from?
Aleppo University Hospital (Syria)
When is the study starting and how long is it expected to run for?
October 2022 to November 2022
Who is funding the study?
Investigator initiated and funded (Syria)
Who is the main contact?
Dr Mohammad Al-Jawad, mhammadjawad877@gmail.com
Contact information
Public, Scientific, Principal Investigator
New Aleppo
Aleppo
963
Syria
| Phone | +963 (0)946148173 |
|---|---|
| mhammadjawad877@gmail.com |
Study information
| Study design | Single-centre observational cross-sectional study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cross sectional study |
| Study setting(s) | Hospital |
| Study type | Diagnostic |
| Participant information sheet | Not available in web format, please use the contact details to request a participant information sheet |
| Scientific title | A comparative study of RIPASA and Alvarado scores in the diagnosis of acute appendicitis: a cross-sectional study |
| Study acronym | CSRAASAACS |
| Study objectives | 1. Importance of accurate diagnosis of acute appendicitis: 1.1. Acute appendicitis is a common surgical emergency that requires prompt diagnosis and treatment to avoid complications like perforation, abscess formation, and peritonitis. 1.2. Accurate diagnosis of acute appendicitis is crucial to ensure timely and appropriate management of patients. 2. Need to evaluate diagnostic scoring systems: 2.1. The RIPASA (Raja Isteri Pengiran Anak Saleha Appendicitis) and Alvarado scoring systems are two commonly used diagnostic tools to aid in the diagnosis of acute appendicitis. 2.2. Evaluating and comparing the performance of these two scoring systems can help determine which one is more accurate and reliable in diagnosing acute appendicitis. 3. Potential clinical implications: 3.1. The findings of this comparative study can have important clinical implications in terms of guiding clinicians in the choice of the most appropriate diagnostic tool for acute appendicitis. 3.2. Identifying the more accurate scoring system can help improve clinical decision-making, reduce unnecessary appendectomies, and optimize patient outcomes. In summary, the rationale for this study is to compare the diagnostic performance of the RIPASA and Alvarado scoring systems in order to determine the more accurate and reliable tool for diagnosing acute appendicitis, which can have significant clinical implications for patient management. |
| Ethics approval(s) | Ethics approval not required |
| Ethics approval additional information | 1. Minimal risk to participants: evaluating the performance of diagnostic scoring systems, such as the RIPASA and Alvarado scores, typically poses minimal risk to patients, as it does not involve any additional tests or treatments beyond standard clinical practice. Since the study is not introducing any new interventions or exposing participants to any undue harm, the risk to patients may be considered low, which can justify a waiver of full ethical approval. 2. Routine clinical practice: the use of diagnostic scoring systems, like the RIPASA and Alvarado scores, is often considered a routine part of clinical practice for the evaluation of suspected acute appendicitis. When the study is focused on the comparative assessment of these established clinical tools, it may be viewed as an extension of standard care and not require additional ethical oversight. |
| Health condition(s) or problem(s) studied | Acute appendicitis |
| Intervention | Patient data was collected through medical history and clinical examination, in addition to conducting the necessary laboratory and radiological investigations and investigating the results. |
| Intervention type | Other |
| Primary outcome measure | Acute appendicitis diagnosis is measured using the RIPASA score and the Alvarado score at baseline (presentation) and 24 hours. This captures the comparison of the two diagnostic scores (RIPASA and Alvarado) for acute appendicitis at the time of initial presentation and again at 24 hours. |
| Secondary outcome measures | There are no secondary outcome measures |
| Overall study start date | 10/10/2022 |
| Completion date | 15/11/2022 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | All |
| Sex | Both |
| Target number of participants | 100 |
| Key inclusion criteria | Each patient who comes to the emergency department with a complaint of severe abdominal pain |
| Key exclusion criteria | Does not meet inclusion criteria |
| Date of first enrolment | 15/10/2022 |
| Date of final enrolment | 10/11/2024 |
Locations
Countries of recruitment
- Syria
Study participating centre
-
Syria
Sponsor information
University/education
Aleppo
Aleppo
963
Syria
| cmoffice@alepuniv.edu.sy | |
| Website | http://www.alepuniv.com/ |
"ROR" |
https://ror.org/03mzvxz96 |
Funders
Funder type
Other
No information available
Results and Publications
| Intention to publish date | 10/11/2024 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Published as a supplement to the results publication |
| Publication and dissemination plan | Planned publication in a peer-reviewed journal |
| IPD sharing plan | The datasets generated and/or analysed during the current study will be published as a supplement to the results publication |
Editorial Notes
28/05/2024: Study's existence confirmed by the Aleppo University Council for Scientific Research and Postgraduate Studies.
