Evaluation of the effects of the Lili screen on the reading performance of dyslexic adults

ISRCTN	ISRCTN14080164
DOI	https://doi.org/10.1186/ISRCTN14080164
Protocol serial number	2025-A00803-46
Sponsor	Lili for Life
Funder	Lili for Life

Submission date: 11/12/2025
Registration date: 29/05/2026
Last edited: 29/05/2026

Recruitment status: Recruiting
Overall study status: Ongoing
Condition category: Mental and Behavioural Disorders

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Background of the study and aims
Dyslexia is a neurodevelopmental disorder linked to brain dysfunction. Its prevalence varies from country to country. To date, it is on the rise, probably due to improved diagnosis and better training of clinicians who treat these patients. Imaging studies (MRI) have reported abnormal processing of visual perception, particularly in the middle temporal lobe of the extrastriate areas, supporting the hypothesis of a visual abnormality in the magnocellular pathway (M cells) in dyslexic individuals. Other studies have shown alterations in the magnocellular system in dyslexia and highlighted the role of this system in the development of normal vision.

To date, no clinical studies have been conducted on the Lili screen. This study is based on the hypothesis that using the Lili screen, with a personalized flicker rate chosen by each subject, for a period of 28 days could significantly improve reading comfort in adult dyslexic subjects. The main objective is to compare the change in reading speed between day 0 and day 28 in dyslexic subjects using the Lili screen in ON mode with the change in reading speed in dyslexic subjects using the Lili screen in OFF mode. Secondary objectives include measuring the effect of the use of the Lili screen over 28 days on (i) eye movement patterns (ii) text comprehension (iii) reading fluidity (iv) oralization capacity (v) oculomotor pattern (vi) visual exploration strategy.

Who can participate ?
Healthy working adult volunteers aged between 18 and 45.

What does the study involve ?
The study involves (i) tests realized on day 0 (ii) the use of the Lili screen over 28 days in the office and at home and (iii) tests realized after 28 days of use of the screen.

What are potential benefits and risks of participating ?
The benefits could be an improvement in all or some of : (i) eye movement patterns (ii) text comprehension (iii) reading fluidity (iv) oralisation capacity (v) oculomotor pattern (vi) visual exploration strategy (vii) reading speed.

There is no risk identified.

Where is the study run from ?
The study is run from various locations in France (universities, companies’ offices and Hôpital Robert Debré).

When is the study starting and when is it expected to end ?
The study starts in September 2025 and runs until December 2026, if not extended.

Who is finding the study ?
Lili For Life, France.

Who is the main contact?
Maria-Pia Bucci, maria-pia.bucci@cnrs.fr

Contact information

Mrs Maria-Pia Bucci
Scientific, Principal investigator

Hôpital Universitaire Robert Debré
63, boulevard Sérurier
Paris
75015
France

ORCID ID	0000-0001-6673-2026
Phone	+ 33 1 40 03 24 79
Email	maria-pia.bucci@cnrs.fr

Liliforlife
Public

Le Village by C A
107 Allee Francois Mitterrand
Rouen
76100
France

Phone	+33 2 78 92 00 10
Email	contact@liliforlife.com

Study information

Primary study design	Interventional
Allocation	Randomized controlled trial
Masking	Blinded (masking used)
Control	Placebo
Assignment	Parallel
Purpose	Device feasibility, Supportive care
Scientific title	Dyslexic adults from 18 to 45 years old. Measuring the effects of the use of the LILI screen, on day 0 and over 28 days, with the use of a lookalike placebo screen over the same period.
Study acronym	ADULTDYSLIGHT
Study objectives	The use of the LILI screen over a period of 28 days contributes to an increase in the speed of reading as well as to an improved comprehension of documents read.
Ethics approval(s)	1. Approved 18/07/2025, Comité de Protection des Personnes Nord Ouest IV (6, rue du Professeur Lagueuse - CHU LILLE - CS 70001, LILLE, 59037, France; + 33 3 20 44 41 65; cppnordouestiv@univ-lille.fr), ref: 25.01308.000410 2. Approved 14/08/2025, National Commission for Information Technology and Freedoms (Commission Nationale Informatique & Libertés - CNIL) (3, place de Fontenoy - TSA 80715, Paris, 75034, France; + 33 1 53 73 22 22; agaignon@cnil.fr), ref: PHT/AGN/AR255494 - DR-2025-189 - Demande d’autorisation n° 925125v1
Health condition(s) or problem(s) studied	Dyslexic persons' reading difficulties
Intervention	The randomization is available in a specific folder, not accessible to the investigator, of the e-Clinical Data Management platform. The subjects are randomized following the block-balancing randomization method to an active group and a placebo group. On the first day of taking part in the study, each participant goes through the first leg of protocolled tests with the Lili screen in mode Off and in mode On. The starting mode (On or Off) is allocated randomly, and neither the participant nor the investigator knows the nature of the starting mode. After the participant has gone through the tests, he/she is randomly allocated two, three and four screens depending on his/her own particular work circumstances (one or two for the office, one or two for home-office). The screens are either On-screens or placebos (Off-Screens). Off-screens and On-screens are lookalikes. Neither the participant nor the investigator is informed of the nature of the screens the participant receives. The participant then works 28 days with the Lili screens in his/her usual office / home-office environment from where the participant’s original screens have been removed. After four weeks of working with the Lili screens, the participant takes part in the second leg of protocolled tests.
Intervention type	Device
Phase	Not Applicable
Drug / device / biological / vaccine name(s)	LILI screen
Primary outcome measure(s)	Reading speed measured using an eye-tracker (seconds) at baseline and day 28
Key secondary outcome measure(s)	1. Reading speed of dyslexic subjects using the Lili screen in OFF mode and then in ON mode measured using an eye-tracker (seconds) at baseline and day 28 2. Reading speed of dyslexic subjects using the Lili screen in ON mode and then in OFF mode measured using an eye-tracker (seconds) at baseline and day 28 3. Reading speed of dyslexic subjects using the Lili screen in ON mode and OFF mode on day 0 measured using an eye-tracker (seconds) at baseline and day 28 4. Eye movement patterns of dyslexic subjects using the Lili screen in ON mode and OFF mode measured using an eye-tracker (seconds) at baseline and day 28 5. Text comprehension of dyslexic subjects using the Lili screen in ON mode and OFF mode measured using an excerpt from a battery of specific tests designed to examine lexical processing in adult subjects. It will be assessed by answering questions about a text after reading aloud (1 min) on day 0 and day 28 6. Reading fluency of dyslexic subjects using the Lili screen in ON mode and OFF mode measures using the number of words read incorrectly and the number of linking errors following the recording of the reading of the same test (microphone) at baseline and day 28 7. Reading ability of dyslexic subjects using the Lili screen in ON mode and OFF mode measured using reading a list of words (regular, irregular, and pseudo-words) and the score for each list, the reading time per list, and the nature of the errors made at baseline and day 28 8. Oralization ability of dyslexic subjects using the Lili screen in ON mode and OFF mode measured using the time taken to complete and the number of errors made during a rapid naming test of images and letters at baseline and day 28 9. Visual and attentional exploration strategy of dyslexic subjects using the Lili screen in ON mode and OFF mode measured using the total number of items correctly found and the time taken to complete the barrage test at baseline and day 28 10. Evaluate participants' feelings measured using a feedback questionnaire at baseline and day 28 11. Evaluate participants' satisfaction measured using a questionnaire (System Usability Scale) on the day the second leg of protocolled tests is performed, after the 28-day period of use of the Lili screens
Completion date	31/12/2026

Eligibility

Participant type(s)	Employee, Learner/student, Population
Age group	Adult
Lower age limit	18 Years
Upper age limit	45 Years
Sex	All
Target sample size at registration	40
Key inclusion criteria	1. Male or female 2. Aged 18 to 45 3. Whose native language is French, 4. Diagnosed with dyslexia (DSM 5, APA. 2013) 5. With normal or corrected vision (≥ 8/10 in each eye) 6. Affiliated to the French social security system.
Key exclusion criteria	1. Subjects with comorbidities (other neurological disorders and/or autism spectrum disorders, dyspraxia, etc.) 2. Subjects with visual impairments (amblyopia, strabismus, etc.) 3. Subjects undergoing psychotropic treatment 4. Subjects with epilepsy 5. Subjects who abuse alcohol (more than 2 drinks per day) 6. Subjects who smoke (≥ 4 cigarettes per day) 7. Subjects who use psychoactive substances such as: 7.1. Psycho-dysleptics: narcotics (heroin, morphine and derivatives), cannabis, ketamine, GHB, LSD, psilocybin, ibogaine 7.2. Psycholeptics: benzodiazepines and related substances (zopiclone, zolpidem) 7.3. Psycho-analeptics: cocaine, amphetamines 8. Pregnant or breastfeeding women 9. Protected adults
Date of first enrolment	08/09/2025
Date of final enrolment	01/12/2026

Locations

Countries of recruitment

France

Study participating centres

VEOLIA

30 rue Madeleine Vionnet
Aubervilliers
93300
France

MAIF

29 rue Brisson
Niort
79000
France

KPMG

Tour Eqho
2, avenue Gambetta
Courbevoie
92400
France

Université de Picardie Jules Verne Service de Médecine et de Prévention des Personnels (SM2P)

Avenue des Facultés -Le Bailly
Amiens Cedex 01
80025
France

Capgemini

145 quai du président Roosevelt
Issy-les-Moulineaux
92130
France

Hôpital Robert Debré

48, boulevard Serrurier
Paris
75019
France

Results and Publications

Individual participant data (IPD) Intention to share	Yes
IPD sharing plan	The datasets generated during and/or analysed during the current study will be available upon request from October 2027. The contact name is Maria-Pia Bucci : maria-pia.bucci@cnrs.fr

Editorial Notes

12/12/2025: Study’s existence confirmed by the National Commission for Information Technology and Freedoms (Commission Nationale Informatique & Libertés - CNIL), France.