Exploring the therapeutic potential of xanthine oxidase inhibitor allopurinol in angina
| ISRCTN | ISRCTN15253766 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN15253766 |
| Protocol serial number | JUS002 |
| Sponsor | University of Dundee (UK) |
| Funder | The British Heart Foundation (UK) |
- Submission date
- 21/02/2006
- Registration date
- 29/03/2006
- Last edited
- 08/11/2011
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Narasimharajapura Rajendra
Scientific
Scientific
Dept of Clinical Pharmacology
Level 7
Ninewells Hospital
Dundee
DD1 9SY
United Kingdom
| Phone | +44 (0)1382 496355 |
|---|
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised double blind placebo-controlled crossover trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Xanthine oxidase inhibition in chronic stable angina improves endothelial function. |
| Ethics approval(s) | Approved by the Regional Ethics Committee on 08/11/2005, reference number: 05/S1401/101 |
| Health condition(s) or problem(s) studied | Chronic stable angina |
| Intervention | Allopurinol versus placebo |
| Intervention type | Drug |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Allopurinol |
| Primary outcome measure(s) |
Change in endothelial function as assessed by: |
| Key secondary outcome measure(s) |
Changes in brain natriuretic peptide (BNP) |
| Completion date | 02/04/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 88 |
| Key inclusion criteria | 1. Documented coronary artery disease 2. Chronic stable angina |
| Key exclusion criteria | 1. Left ventricular systolic dysfunction 2. Renal failure 3. Concomitant warfarin therapy 4. Allergy to allopurinol |
| Date of first enrolment | 05/01/2006 |
| Date of final enrolment | 02/04/2008 |
Locations
Countries of recruitment
- United Kingdom
- Scotland
Study participating centre
Dept of Clinical Pharmacology
Dundee
DD1 9SY
United Kingdom
DD1 9SY
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 16/08/2011 | Yes | No |
