A prospective randomised, double-blind controlled trial of intravenous aminophylline versus placebo in patients with acute exacerbations of COPD

ISRCTN	ISRCTN17312089
DOI	https://doi.org/10.1186/ISRCTN17312089
Protocol serial number	N0025107117
Sponsor	Department of Health (UK)
Funder	Aintree Hospitals NHS Trust (UK)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Dr Paul Walker
Scientific

Chest Unit
3rd Floor Clinical Science Building
University Hospital Aintree
Longmoor Lane
Liverpool
L9 7AL
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	Whether intravenous aminophylline provides any benefit to patients with acute exacerbations of COPD.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Respiratory: Chronic obstructive pulmonary disease (COPD)
Intervention	Intravenous aminophylline vs placebo
Intervention type	Other
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	01/02/2005

Participant type(s)	Patient
Age group	Adult
Sex	Not Specified
Target sample size at registration	80
Key inclusion criteria	80 adult subjects aged 40-80 years.
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/02/2002
Date of final enrolment	01/02/2005

Chest Unit

Liverpool
L9 7AL
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/09/2005		Yes	No