Ultra low dose anticoagulation in atrial fibrillation
| ISRCTN | ISRCTN17465143 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN17465143 |
| Protocol serial number | MC7 |
| Sponsor | Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK) |
| Funder | NHS Cardiovascular Disease and Stroke National Research and Development Programme (UK) |
- Submission date
- 23/01/2004
- Registration date
- 23/01/2004
- Last edited
- 30/08/2012
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Gareth Beevers
Scientific
Scientific
University Department of Medicine
City Hospital
Dudley Rd
Birmingham
B18 7QH
United Kingdom
| Phone | +44 (0)121 507 5080 |
|---|
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Previous studies have demonstrated increased markers of thrombogenesis in patients with atrial fibrillation (AF), suggesting the presence of a hypercoaguable or prothromobotic state. The objective of this study was to determine the effects of introducing ultra-low-dose warfarin (1 mg), conventional warfarin, and aspirin (300 mg) therapy on thrombogenesis and platelet activation in AF. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Heart disease |
| Intervention | 3 treatment arms: 1. Ultra-low-dose warfarin (1 mg) 2. Conventional warfarin 3. Aspirin (300 mg) |
| Intervention type | Drug |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Warfarin, aspirin |
| Primary outcome measure(s) |
Platelet activation |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 01/04/1996 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Key inclusion criteria | Patients with atrial fibrillation |
| Key exclusion criteria | Does not match inclusion criteria |
| Date of first enrolment | 01/04/1994 |
| Date of final enrolment | 01/04/1996 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
University Department of Medicine
Birmingham
B18 7QH
United Kingdom
B18 7QH
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/08/1996 | Yes | No |
