A trial to compare radiotherapy alone with radiotherapy followed by chemotherapy in the treatment of non-Hodgkin's lymphoma
| ISRCTN | ISRCTN18173987 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN18173987 |
| Protocol serial number | NHD1 |
| Sponsor | Cancer Research UK (CRUK) (UK) |
| Funder | Cancer Research UK |
- Submission date
- 01/07/2001
- Registration date
- 01/07/2001
- Last edited
- 15/01/2019
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Cancer
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr - -
Scientific
Scientific
UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
London
NW1 2DA
United Kingdom
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | A trial to compare radiotherapy alone with radiotherapy followed by chemotherapy in the treatment of non-Hodgkin's lymphoma |
| Study objectives | Not provided at time of registration |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Lymphoma (non-Hodgkin's) |
| Intervention | 1. Group A: Radical radiotherapy, 30 Gy in 15 fractions over 3 weeks 2. Group B: Radical radiotherapy, 30 Gy in 15 fractions over 3 weeks followed 1 month later by chemotherapy. Chemotherapy with chlorambucil for 14 consecutive days repeated every 28 days for 2 years. |
| Intervention type | Mixed |
| Primary outcome measure(s) |
Not provided at time of registration |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 03/11/1992 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Key inclusion criteria | 1. Aged 15-65 years 2. Proven non-Hodgkin's disease with good pathology involving nodes, Waldeyer's ring is also included provided that nodes are also involved 3. Stage I or II |
| Key exclusion criteria | Patients with abdominal nodes only are excluded |
| Date of first enrolment | 01/01/1990 |
| Date of final enrolment | 03/11/1992 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
MRC Clinical Trials Unit
London
NW1 2DA
United Kingdom
NW1 2DA
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
Editorial Notes
15/01/2019: No publications found. All search options exhausted.
