A pilot study to determine the effects of corticotrophin releasing hormone (CRH) on myocardial function
| ISRCTN | ISRCTN18842004 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN18842004 |
| Protocol serial number | N0295132800 |
| Sponsor | Department of Health |
| Funder | University Hospitals Coventry and Warwickshire NHS Trust (UK) |
- Submission date
- 30/09/2004
- Registration date
- 30/09/2004
- Last edited
- 07/07/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Harpal Randeva
Scientific
Scientific
Metabolic Unit
Coventry & Warwickshire Hospital
Stoney Stanton Road
Coventry
CV1 4FH
United Kingdom
| Phone | +44 (0)2476 844091/572552 |
|---|---|
| harpal.randeva@uhcw.nhs.uk |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Double-blind randomised crossover pilot study |
| Secondary study design | Randomised cross over trial |
| Study type | Participant information sheet |
| Scientific title | A pilot study to determine the effects of corticotrophin releasing hormone (CRH) on myocardial function |
| Study objectives | What is the effect of a single intravenous dose of CRH on myocardial contractility in normal, healthy subjects? |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Cardiovascular: Myocardial function |
| Intervention | Single intravenous dose of CRH |
| Intervention type | Drug |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Corticotrophin releasing hormone |
| Primary outcome measure(s) |
Changes in measure of cardiac contractility/function as assessed by echocardiography: ejection fraction, fractional shortening, stroke volume, diastolic left ventricular filling, myocardial velocity, strain rate and strain. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 30/04/2004 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 60 Years |
| Sex | All |
| Target sample size at registration | 10 |
| Key inclusion criteria | Healthy men or women, 18-60 years of age. |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 08/12/2003 |
| Date of final enrolment | 30/04/2004 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Coventry & Warwickshire Hospital
Coventry
CV1 4FH
United Kingdom
CV1 4FH
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
Editorial Notes
07/07/2017: No publications found in PubMed, verifying study status with principal investigator.
