Adjunctive benefits of systemic antibiotics to non-surgical treatment of generalised aggressive (early onset) periodontitis: a pilot study investigating treatment outcomes and prevalence and persistence of antibiotic resistance.
| ISRCTN | ISRCTN19566213 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN19566213 |
| Protocol serial number | N0263128690 |
| Sponsor | Department of Health |
| Funder | University College London Hospitals NHS Trust (UK) |
- Submission date
- 30/09/2004
- Registration date
- 30/09/2004
- Last edited
- 29/07/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Oral Health
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr G S Griffiths
Scientific
Scientific
Periodontology
Periodontology Department
Eastman Dental Institute
256 Gray's Inn Road
London
WC1X 8LD
United Kingdom
| Phone | +44 (0)20 7 915 1074 |
|---|
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Does the use of systemic antibiotics have an adjunctive effect over mechanical cleaning and does it lead to an increase in antibiotics resistance? |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Periodontology; periodontitis |
| Intervention | Patients with periodontitis undergoing mechanical cleaning will be randomised to receive 1. Antibiotic 2.. Placebo |
| Intervention type | Other |
| Primary outcome measure(s) |
Changes in bleeding on probing, probeable crevice depth and lifetime attachment loss. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 01/07/2004 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | All |
| Target sample size at registration | 40 |
| Key inclusion criteria | 40 patients from Periodontology |
| Key exclusion criteria | Does not match inclusion criteria |
| Date of first enrolment | 01/04/2003 |
| Date of final enrolment | 01/07/2004 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Periodontology
London
WC1X 8LD
United Kingdom
WC1X 8LD
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/10/2005 | Yes | No |
