Randomised controlled study of Lubrication with and without Bandage Contact Lens in primary treatment of Recurrent Corneal Erosion Syndrome

ISRCTN	ISRCTN22866928
DOI	https://doi.org/10.1186/ISRCTN22866928
Protocol serial number	N0199166145
Sponsor	Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Funders	Royal Berkshire and Battle Hospitals NHS Trust, NHS R&D Support Funding

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Mr Maghizh Anandan
Scientific

Department of Ophthamology
Eye Block
Royal Berkshire Hospital
London Road
Reading
RG1 5AN
United Kingdom

Phone	+44 0118 322 8150

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title
Study objectives	To compare lubrication alone as a treatment of recurrent corneal erosion against bandage contact lenses with lubrication on the rate of healing and subsequent recurrence of corneal ersion.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Eye Diseases: Recurrent corneal erosion syndrome
Intervention	Prospective, randomised controlled trial comparing lubrication alone as a treatment of recurrent corneal erosion against bandage contact lenses with lubrication on the rate of healing and subsequent recurrence of corneal erosions. Target 20 patients per group.
Intervention type	Other
Primary outcome measure(s)	1. Rate of healing and subsequent recurrence of corneal erosion 2. Symptom control 3. Incidence of adverse outcomes, particularly corneal infection
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	30/06/2008

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target sample size at registration	40
Key inclusion criteria	All patients diagnosed with Recurrent Corneal Erosion Syndrome (RCES) seen in eye casualty on the basis of spontaneously recurring focal epithelial defect of epithelial defect diagnosed for the first time with characteristic symptoms of RCE
Key exclusion criteria	1. RCE with evidence of infection, as the management will differ due to infection 2. Patients with any other corneal pathology and those who have had surgical treatments for RCE in the past as they may affect the outcome of the study
Date of first enrolment	08/08/2005
Date of final enrolment	30/06/2008

Department of Ophthamology

Reading
RG1 5AN
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/06/2011		Yes	No
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes