In elderly patients over 90 years old with acute kidney injury post-infection, does prolonged intermittent renal replacement therapy improve outcomes compared to standard therapy?
| ISRCTN | ISRCTN24896690 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN24896690 |
- Submission date
- 18/08/2024
- Registration date
- 19/08/2024
- Last edited
- 19/08/2024
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Urological and Genital Diseases
Plain English summary of protocol
Background and study aims
This study investigates the effectiveness of a specialized treatment called Prolonged Intermittent Renal Replacement Therapy (PIRRT) in elderly patients over 90 years old who develop acute kidney injury (AKI) following an infection. The goal is to understand how well this treatment works in such elderly patients and to identify factors that affect their survival.
Who can participate?
The study was conducted on elderly patients aged 90 and above who developed AKI after an infection and were treated at the China-Japan Friendship Hospital.
What does the study involve?
We collected and analyzed medical data from patients treated with PIRRT over the past five years. The study focuses on their treatment outcomes and the factors that may influence their survival.
What are the possible benefits and risks of participating?
The findings suggest that nearly half of the elderly patients survived for more than 90 days after receiving PIRRT, indicating that this treatment can be effective. However, patients with pre-existing chronic kidney disease, certain complications like low calcium levels, rapid heart rates, or high potassium levels had a poorer prognosis.
Where is the study run from?
China-Japan Friendship Hospital (China)
When is the study starting and how long is it expected to run for?
June 2019 to May 2024
Who is funding the study?
This research is funded by the National Natural Science Foundation (China) (82304363)
Who is the main contact?
Dr Zheng Zhang, 88dahongmao88@sina.com
Contact information
Public, Scientific, Principal Investigator
No. 2, Yinghua East Street, Chaoyang District
Beijing
100029
China
 ORCID ID |
0000-0002-8480-1555 |
|---|---|
| Phone | +86 18811414199 |
| 88dahongmao88@sina.com |
Study information
| Study design | Observational single-center retrospective cohort study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cohort study |
| Study setting(s) | Hospital |
| Study type | Efficacy |
| Participant information sheet | Not applicable (retrospective study) |
| Scientific title | Prolonged intermittent renal replacement therapy in elderly patients over 90 years old with acute kidney injury post-infection: a retrospective cohort study |
| Study objectives | Prolonged intermittent renal replacement therapy (PIRRT) improves clinical outcomes compared to standard therapy in elderly patients over 90 with acute kidney injury following infection. |
| Ethics approval(s) |
Approved 27/09/2016, China-japan Friendship Hospital Clinical Research Ethics Committee (2 Yinghua East Street, Chaoyang District, Beijing, 100029, China; +86 10 66937166; zryyec@126.com), ref: S2016-100-01 |
| Health condition(s) or problem(s) studied | Renal replacement therapy for acute kidney injury after infection in elderly patients |
| Intervention | Using prolonged intermittent renal replacement therapy (PIRRT), observe patient survival time and explore the correlation between clinical factors and prognosis. |
| Intervention type | Procedure/Surgery |
| Primary outcome measure | Measured using patient records: 1. Age at baseline 2. Gender at baseline 3. Systolic Blood Pressure: Average all measurements taken from baseline over the next 3 days 4. Diastolic Blood Pressure: Average all measurements taken from baseline over the next 3 days 5. Heart Rate: Average all measurements taken from baseline over the next 3 days 6. Creatinine at baseline 7. Estimated Glomerular Filtration Rate at baseline 8. Urea at baseline 9. Sodium at baseline 10. Potassium at baseline 11. Calcium at baseline 12. Phosphorus at baseline 13. B-type Natriuretic Peptide at baseline 14. Hemoglobin at baseline 15. White Blood Cell Count at baseline 16. Neutrophil Count at baseline 17. Lymphocyte Count at baseline 18. Platelet Count at baseline 19. C-Reactive Protein at baseline 20. Procalcitonin at baseline 21. Prothrombin Time at baseline 22. Activated Partial Thromboplastin Time at baseline 23. SOFA Score at baseline 24. APACHE II Score at baseline |
| Secondary outcome measures | There are no secondary outcome measures |
| Overall study start date | 01/06/2019 |
| Completion date | 01/05/2024 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 90 Years |
| Upper age limit | 150 Years |
| Sex | Both |
| Target number of participants | 30 |
| Total final enrolment | 20 |
| Key inclusion criteria | 1. Patients over 90 years old 2. Acute kidney injury (AKI) due to infection 3. Received Prolonged Intermittent Renal Replacement Therapy (PIRRT) |
| Key exclusion criteria | Does not meet inclusion criteria |
| Date of first enrolment | 01/06/2019 |
| Date of final enrolment | 01/05/2024 |
Locations
Countries of recruitment
- China
Study participating centre
Beijing
100029
China
Sponsor information
Hospital/treatment centre
No. 2, Yinghua East Street, Chaoyang District
Beijing
100029
China
| Phone | +86 10 62328941 |
|---|---|
| support@nsfc.gov.cn | |
| Website | https://www.zryhyy.com.cn/ |
"ROR" |
https://ror.org/037cjxp13 |
Funders
Funder type
Government
Government organisation / National government
- Alternative name(s)
- Chinese National Science Foundation, Natural Science Foundation of China, National Science Foundation of China, NNSF of China, NSF of China, 国家自然科学基金委员会, National Nature Science Foundation of China, Guójiā Zìrán Kēxué Jījīn Wěiyuánhuì, NSFC, NNSF, NNSFC
- Location
- China
Results and Publications
| Intention to publish date | 01/09/2024 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Available on request |
| Publication and dissemination plan | Planned publication in a peer-reviewed journal. |
| IPD sharing plan | The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request, 88dahongmao88@sina.com |
Editorial Notes
19/08/2024: Trial's existence confirmed by China-japan Friendship Hospital Clinical Research Ethics Committee.
