Are the psychoto-mimetic effects of cannabis mediated via dopamine?
| ISRCTN | ISRCTN27139591 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN27139591 |
| Protocol serial number | N0263181140 |
| Sponsor | Record Provided by the NHSTCT Register - 2007 Update - Department of Health |
| Funders | University College London Hospitals NHS Foundation Trust (UK), NHS R&D Support Funding (UK) |
- Submission date
- 28/09/2007
- Registration date
- 28/09/2007
- Last edited
- 14/10/2014
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Mental and Behavioural Disorders
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof - -
Scientific
Scientific
Institute of Nuclear Medicine
University College Hospital
5th Floor
235 Euston Road
London
NW1 2BU
United Kingdom
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Are the transient psychotic like effects induced by delta-9-tetrahydrocannibinol correlated with excess dopamine release in the striatum as measures by (123I)-IBZM single photon emission tomography (SPET)? |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Mental and Behavioural Disorders: Psychosis |
| Intervention | 1. THC drug 2. Placebo |
| Intervention type | Drug |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Cannabis |
| Primary outcome measure(s) |
1. The percentage decrease in specific (123I)-IBZM binding under THC vs placebo conditions |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 01/12/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Key inclusion criteria | External patients |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/06/2006 |
| Date of final enrolment | 01/12/2007 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
Institute of Nuclear Medicine
London
NW1 2BU
United Kingdom
NW1 2BU
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
