Secondary prevention of cardiovascular disease in general practice.

ISRCTN	ISRCTN27780786
DOI	https://doi.org/10.1186/ISRCTN27780786
Protocol serial number	MC10
Sponsor	Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)
Funder	NHS Cardiovascular Disease and Stroke National Research and Development Programme (UK)

Submission date: 23/01/2004
Registration date: 23/01/2004
Last edited: 20/11/2009

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Circulatory System

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Prof David Mant
Scientific

Institute of Health Sciences
University of Oxford
Old Road
Headington
Oxford
OX3 7LF
United Kingdom

Phone	+44 (0)1865 226 770
Email	david.mant@dphpc.ox.ac.uk

Study information

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	Patients with established coronary heart disease have a lower mortality rate and less morbidity if they make changes in their behaviour (smoking, diet, exercise, weight), and are given appropriate medication (aspirin, beta blockers, lipid lowering drugs etc). Achieving these interventions involves collaboration between patients and families, hospital staff, and primary care teams which is often not done well. The main aim of this study was to see if the use of specialist liaison nurses to co-ordinate care at hospital discharge and to support existing rehabilitation and primary care services was cost-effective in reducing morbidity and cardiovascular risk in the year after myocardial infarction.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Heart disease
Intervention	1. Use of liaison nurses - sought to co-ordinate care, support the patient and family, support the practice nurses, and support the cardiac rehabilitation programme. The liaison nurses were not involved with management of individual patients but sought to encourage the use of current models of behaviour change, achieve a structured programme for each patient, and promote the use of effective treatments. 2. No use of liaison nurses, i.e. standard care
Intervention type	Other
Primary outcome measure(s)	1. At assessment demographic data and information on smoking and diet were collected. The patient's weight, height, blood pressure, and blood cholesterol were measured. 2. The three questionnaires asked about smoking, exercise, and diet; drug treatment; attendance at rehabilitation and other health services; and symptoms of pain and breathlessness. 3. Psychological state was assessed using the Hospital Anxiety and Depression scale 4. Quality of life using the Euroqual scale 5. At 12 months the clinical examination repeated the baseline measurements, together with a measurement of blood cotinine in those who had ever smoked, and a 6 minute exercise test.
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	01/07/1997

Eligibility

Participant type(s)	Patient
Age group	Other
Sex	All
Target sample size at registration	597
Key inclusion criteria	597 patients from 67 practices in Southampton and South-West Hampshire who had been admitted to hospital or attended a chest pain clinic with a myocardial infarct or recent-onset angina were recruited to the study. 38 patients died within 12 months. Follow up rates were about 90%.
Key exclusion criteria	Does not match inclusion criteria
Date of first enrolment	01/01/1995
Date of final enrolment	01/07/1997

Locations

Countries of recruitment

United Kingdom
England

Study participating centre

Institute of Health Sciences

Oxford
OX3 7LF
United Kingdom

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/12/1998		Yes	No
Results article	results	13/03/1999		Yes	No