Does exercise training result in weight loss?
| ISRCTN | ISRCTN31641049 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN31641049 |
| Secondary identifying numbers | N/A |
- Submission date
- 20/11/2018
- Registration date
- 04/01/2019
- Last edited
- 27/02/2023
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nutritional, Metabolic, Endocrine
Plain English summary of protocol
Background and study aims
Physical activity or exercise, by increasing the energy expended during the day, would appear to be an efficient tool to prevent and possibly treat obesity. However, the impact of exercise on body weight and composition is often much less than anticipated. Lean individuals who are regular exercisers usually maintain a stable body weight, but this study aimed to determine whether this was also the case for obese individuals.
Who can participate?
Women who are overweight or obese.
What does the study involve?
Participants had to train for 3-months at a low or high intensity and expend 1500 kcal per week.
What are the possible benefits and risks of participating?
Participating in the study allowed participants to access a gym for free and get more active.
Where is the study run from?
University of Ottawa
When is the study starting and how long is it expected to run for?
September 2010 to December 2012
Who is funding the study?
University of Ottawa
Who is the main contact?
Éric Doucet
edoucet@uottawa.ca
Contact information
Scientific
Behavioural and Metabolic Research Unit (BMRU), School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Ottawa
K1N 6N5
Canada
| Phone | 613-562-5800 poste/ext. 7364 |
|---|---|
| eric.doucet@uottawa.ca |
Study information
| Study design | Interventional single-centre repeated measures randomised parallel trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised parallel trial |
| Study setting(s) | Other |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use the contact details to request a participant information sheet |
| Scientific title | Comparing high and low intensity supervised exercise interventions on energy compensation in overweight or obese women : a randomised parallel trial |
| Study objectives | Women training at high intensity will have higher energy compensation across the intervention due to greater energy intake. Non-structured physical activity will decrease more in women training at high intensity vs lower intensity. |
| Ethics approval(s) | University of Ottawa Ethics Committee, 24/01/2011, H10-10-03 |
| Health condition(s) or problem(s) studied | Overweight and obesity in women |
| Intervention | We conducted a 3-month exercise training program at a low or high intensity. Participants had to train 5 times per week and had to achieve 300 kcal per exercise session for a total of 1500 kcal/week. Participants were tested (during 7-day) 1 month before the exercise intervention; a 14-day phase at the onset of the exercise intervention (wk 1, wk 2); and a 7-day phase at the end of the 3-month exercise intervention (wk 12). |
| Intervention type | Behavioural |
| Primary outcome measure | The following were assessed during 3 data collection phases - a 7 day baseline phase (1 month prior to the exercise intervention), a 14 day phase at the beginning of the intervention, and a 7 day phase at the end of the intervention (after 3 months): 1. Energy intake, assessed using lunch boxes and a food journal (according to McNeil et al., 2012) 2. Energy expenditure, assessed using doubly labelled water (according to Schoeller and van Santen, 1982). 3. Body composition, assessed using dual X-ray absorptiometry |
| Secondary outcome measures | The following were assessed during 3 data collection phases - a 7 day baseline phase (1 month prior to the exercise intervention), a 14 day phase at the beginning of the intervention, and a 7 day phase at the end of the intervention (after 3 months): 1. Appetite, assessed using a visual analogue scale (VAS) 2. Eating behaviour traits, assessed using the Three-Factor Eating Questionnaire (TFEQ) 3. Food rewards, assessed using the Leeds Food Preference Questionnaire (LFPQ) 4. Time spent performing activities, assessed using an accelerometer |
| Overall study start date | 01/09/2010 |
| Completion date | 11/12/2012 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Adult |
| Sex | Female |
| Target number of participants | 21 participants (11 in the low intensity group and 10 in the high intensity group) |
| Total final enrolment | 21 |
| Key inclusion criteria | 1. Aged 20-45 years 2. Female 3. Stable weight for the last 2 months 4. Body mass index (BMI) >30 kg/m² 5. Sedentary (no more than 2 hours of structured physical activity per week) 6. Menstrual periods every month |
| Key exclusion criteria | 1. Pregnancy 2. Smokers 3. Drug users 4. Consuming more than 2 units of alcohol per day 5. Claustrophobic 6. Use of nutritional supplements 7. Not using oral contraceptives or hormones 8. Diabetic (type 1 or type 2) 9. Thyroid disorders 10. Renal disease 11. Liver disease 12. Cancer 13. Inflammatory disease 14. Asthma 15. Respiratory problems 16. Cardiovascular disease 17. Peripheral vascular disease 18. Stroke 19. Orthopaedic limitations 20. Using any of the following: 20.1. Systemic corticosteroids (e.g. prednisone) 20.2. Anti-obesity agents (e.g. Xenical®, Meridia®) 20.3. Natural supplemented for weight loss or weight control (e.g. Megace) 20.4. Antipsychotics 20.5. Mood stabilisers or antidepressants that have a significant impact on weight (e.g. Zyprexa®, Remeron®) 20.6. Diuretics (e.g. Lasix®, furosemide) 21. Treatment with thyroid hormones (stable dose for at least 3 months before the start of the study) 22. Use of thiazide diuretics (hydrochlotozide) for less than 3 months |
| Date of first enrolment | 25/01/2011 |
| Date of final enrolment | 11/09/2012 |
Locations
Countries of recruitment
- Canada
Study participating centre
Ottawa
K1N 6N5
Canada
Sponsor information
University/education
School of Human Kinetics
Ottawa
K1N 6N5
Canada
| Website | uottawa.ca |
|---|---|
"ROR" |
https://ror.org/03c4mmv16 |
Funders
Funder type
Other
No information available
Results and Publications
| Intention to publish date | 26/11/2018 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Available on request |
| Publication and dissemination plan | The full study is currently under review at Frontiers in Physiology. |
| IPD sharing plan | The datasets generated and/or analysed during the current study are available on request from Marie-Ève Riou (mriou039@uottawa.com). All the data is already collected and is in binders in a locked room. The consent forms for each individual are kept in a separate binder in another locked room. Participant anonymity in the data is fully respected and names are not included. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Basic results | 05/12/2018 | 04/01/2019 | No | No | |
| Results article | 22/08/2019 | 27/02/2023 | Yes | No |
Additional files
- ISRCTN31641049_BasicResults_5Dec18.pdf
- Uploaded 04/01/2019
Editorial Notes
27/02/2023: Publication reference and total final enrolment added.
11/01/2019: Internal review.
