Gene-lifestyle interactions and complex traits Involved in elevated disease risk
| ISRCTN | ISRCTN35275922 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN35275922 |
| Protocol serial number | Dnr 2015-197-32M |
| Sponsor | Umeå University Department of Biobank Research |
| Funders | Vetenskapsrådet, Novo Nordisk, Hjärt-Lungfonden, Diabetesförbundet |
- Submission date
- 05/10/2017
- Registration date
- 17/11/2017
- Last edited
- 17/11/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Ongoing
- Condition category
- Circulatory System
Plain English summary of protocol
Background and study aims
Since 1986, all residents of the northern Swedish county of Västerbotten who turned 40, 50 and/or 60 years are invited to visit the primary care centre. The aim of this study is to use the extensive data collected as part of this ongoing health survey in order to address questions related to lifestyle and genetic risk factors in cardiometabolic disease (e.g., heart disease and type 2 diabetes).
Who can participate?
Adults aged 40, 50, and 60 from Västerbotten
What does the study involve?
Patients complete a detailed lifestyle questionnaire and provide blood samples. The blood sample is used to measure blood glucose (sugar), blood lipids (fat, cholesterol), and genetic information. The data is used to find out whether lifestyle/environmental factors affect the link between genetics and human character (e.g. body mass index, blood glucose).
What are the possible benefits and risks of participating?
Participants receive some health-related advice as part of the background study, which may be perceived as a benefit. Risks include those related to the handling of sensitive personal data. There are no significant treatment-related risks.
Where is the study run from?
Primary Care Center in Västerbotten (Sweden)
When is the study starting and how long is it expected to run for?
January 1986 to December 2025
Who is funding the study?
1. Swedish Research Council (Sweden)
2. Novo Nordisk (Denmark)
3. Swedish Heart-Lung Foundation (Sweden)
4. Swedish Diabetes Association (Sweden)
Who is the main contact?
Prof. Paul Franks
Contact information
Scientific
Department of Clinical Sciences, Genetic and Molecular Epidemiology
CRC, Building 91, Level 10
Jan Waldenströms gata 35
Skåne University Hospital Malmö
Malmö
21428
Sweden
Study information
| Primary study design | Observational |
|---|---|
| Study design | Prospective population-based cohort study |
| Secondary study design | Cohort study |
| Study type | Participant information sheet |
| Scientific title | Gene-lifestyle interactions and complex traits involved in elevated disease risk: a prospective population-based cohort study |
| Study acronym | GLACIER |
| Study objectives | The GLACIER study was designed to estimate the separate and combined effects of genetic and lifestyle factors in cardiometabolic disease. |
| Ethics approval(s) | The Regional Ethics Review Board in Umeå, 21/10/2010, ref: Dnr 2015-197-32M |
| Health condition(s) or problem(s) studied | Cardiovascular disease and type 2 diabetes |
| Intervention | All participants are asked to complete a questionnaire concerning various lifestyle factors including diet and to donate a blood sample for for later research purposes. The blood samples were then measured for blood glucose, blood lipid profiles (e.g. triglyceride, HDL-cholesterol) and for genetic information. Body weight and height were measured. The study is focused on whether lifestyle/environmental factors influence the association between genetics and human character (e.g. body mass index, blood glucose). |
| Intervention type | Mixed |
| Primary outcome measure(s) |
Many hundreds of exposure and outcome variables including type 2 diabetes, myocardial infarction and stroke, derived from health survey data every 10 years |
| Key secondary outcome measure(s) |
Secondary outcomes include quantitative cardiometabolic traits (e.g., blood pressure, glucose, and lipids, and anthropometry) usually assessed in the year of each participant’s 40, 50, 60th or 70th birthdays. Examinations occurred between 1986 and 2007 |
| Completion date | 31/12/2025 |
Eligibility
| Participant type(s) | Mixed |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 100000 |
| Key inclusion criteria | All individuals 40, 50, and 60 years of age in the county’s population are invited |
| Key exclusion criteria | People who are not able to consent or not living in the county |
| Date of first enrolment | 01/01/1986 |
| Date of final enrolment | 01/01/2020 |
Locations
Countries of recruitment
- Sweden
Study participating centre
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not expected to be made available |
| IPD sharing plan | The datasets generated during and/or analysed during the current study is not expected to be made available due to consenting constraints. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
