Role of epidermal apoptosis in the clearance of psoriatic plaques

ISRCTN	ISRCTN38471512
DOI	https://doi.org/10.1186/ISRCTN38471512
Protocol serial number	6639
Sponsor	Newcastle upon Tyne Hospitals NHS Foundation Trust
Funder	Psoriasis Association (UK)

Submission date: 12/05/2010
Registration date: 12/05/2010
Last edited: 28/03/2018

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Skin and Connective Tissue Diseases

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Sophie Weatherhead
Scientific

Newcastle University
Dermatology
2nd Floor William Leech Building
Medical School
Newcastle
NE2 4HH
United Kingdom

Study information

Primary study design	Observational
Study design	Single centre non-randomised trial
Secondary study design	Single-centre
Study type	Participant information sheet
Scientific title	Role of epidermal apoptosis in the clearance of psoriatic plaques: a single centre non-randomised trial
Study acronym	MECH-PSOR-CLEAR
Study objectives	To investigate whether anti-psoriatic treatments induce epidermal apoptosis, and whether this may account for plaque clearance.
Ethics approval(s)	MREC approved (ref: 2002/255)
Health condition(s) or problem(s) studied	Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology
Intervention	Biopsies (skin).
Intervention type	Other
Primary outcome measure(s)	Apoptotic epidermal cells
Key secondary outcome measure(s)	Effect of gender, age and treatment
Completion date	30/04/2013

Eligibility

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target sample size at registration	100
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/09/2002
Date of final enrolment	30/04/2013

Locations

Countries of recruitment

United Kingdom
England

Study participating centre

Newcastle University

Newcastle
NE2 4HH
United Kingdom

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes

Editorial Notes

28/03/2018: No publications found, verifying study status with principal investigator.
05/02/2016: No publications found, verifying study status with principal investigator