The effect of clodronate on the incidence of hip fracture and consequences for health and costs

ISRCTN	ISRCTN39259790
DOI	https://doi.org/10.1186/ISRCTN39259790
Protocol serial number	G9518113
Sponsor	Medical Research Council (MRC) (UK)
Funder	Medical Research Council (UK)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Dr EV McCloskey
Scientific

Department of Human Metabolism & Clinical Biochemistry
University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	To determine in an elderly female population who would best benefit from an intervention aimed at reducing the incidence of hip fracture
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Orthopaedics, rheumatology
Intervention	Clodronate/control
Intervention type	Other
Primary outcome measure(s)	Fragility fractures, particularly hip fracture
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	01/12/2002

Participant type(s)	Patient
Age group	Senior
Sex	Female
Target sample size at registration	5700
Key inclusion criteria	Women aged 75 years or older willing to participate
Key exclusion criteria	Drugs and diseases likely to impair the efficacy of intervention or the interpretation of results
Date of first enrolment	10/06/1996
Date of final enrolment	01/12/2002

Department of Human Metabolism & Clinical Biochemistry

Sheffield
S10 2RX
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	Results	01/01/2007		Yes	No