Mechanisms of transiently impaired renal function during liver transplantation
| ISRCTN | ISRCTN43452247 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN43452247 |
| Protocol serial number | CER 03-159; SHR 369-08 |
| Sponsor | Geneva University Hospitals (Hôpitaux Universitaires de Genève) (Switzerland) |
| Funder | Geneva University Hospitals (Hôpitaux Universitaires de Genève) (Switzerland) |
- Submission date
- 21/06/2008
- Registration date
- 12/09/2008
- Last edited
- 12/09/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Urological and Genital Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Eduardo Schiffer
Scientific
Scientific
Hopitaux Universitaires de Geneve
24 Micheli-du-Crest
Geneva
1211
Switzerland
Study information
| Primary study design | Observational |
|---|---|
| Study design | Observational, prospective, cross-sectional study |
| Secondary study design | Cross-section survey |
| Scientific title | Renal function during the perioperative period of liver transplantation |
| Study objectives | Hyperreninism is the major mediator of transient and acute anuria during the anhepatic phase of liver transplantation. |
| Ethics approval(s) | Ethics Committee of the Geneva University Hospitals (Commission central d'éthique de la recherche sur l'être humain des HUG). Date of approval: 24/01/2004 (ref: CER 03-159) |
| Health condition(s) or problem(s) studied | Liver transplantation |
| Intervention | Observational study: Blood sampling for biologic assessment of renal function at the time of inclusion in the waiting list, at the time of anaesthesia induction on the day of liver transplantation, during the anhepatic phase, 24 hours later and finally at 6 months. |
| Intervention type | Other |
| Primary outcome measure(s) |
Renal function: plasma renin activity, assessed in all blood samples (see Interventions). |
| Key secondary outcome measure(s) |
The following were assessed in all blood samples (see Interventions): |
| Completion date | 01/01/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 30 |
| Key inclusion criteria | 1. Both males and females 2. Age 17-70 years 3. Patients scheduled for liver transplantation |
| Key exclusion criteria | Incapacity to comprehend the study protocol |
| Date of first enrolment | 01/08/2004 |
| Date of final enrolment | 01/01/2008 |
Locations
Countries of recruitment
- Switzerland
Study participating centre
Hopitaux Universitaires de Geneve
Geneva
1211
Switzerland
1211
Switzerland
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
