Mechanisms of transiently impaired renal function during liver transplantation
| ISRCTN | ISRCTN43452247 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN43452247 |
| Secondary identifying numbers | CER 03-159; SHR 369-08 |
- Submission date
- 21/06/2008
- Registration date
- 12/09/2008
- Last edited
- 12/09/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Urological and Genital Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Eduardo Schiffer
Scientific
Scientific
Hopitaux Universitaires de Geneve
24 Micheli-du-Crest
Geneva
1211
Switzerland
Study information
| Study design | Observational, prospective, cross-sectional study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cross-section survey |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | Renal function during the perioperative period of liver transplantation |
| Study objectives | Hyperreninism is the major mediator of transient and acute anuria during the anhepatic phase of liver transplantation. |
| Ethics approval(s) | Ethics Committee of the Geneva University Hospitals (Commission central d'éthique de la recherche sur l'être humain des HUG). Date of approval: 24/01/2004 (ref: CER 03-159) |
| Health condition(s) or problem(s) studied | Liver transplantation |
| Intervention | Observational study: Blood sampling for biologic assessment of renal function at the time of inclusion in the waiting list, at the time of anaesthesia induction on the day of liver transplantation, during the anhepatic phase, 24 hours later and finally at 6 months. |
| Intervention type | Other |
| Primary outcome measure | Renal function: plasma renin activity, assessed in all blood samples (see Interventions). |
| Secondary outcome measures | The following were assessed in all blood samples (see Interventions): 1. Cystatin C 2. Natraemia |
| Overall study start date | 01/08/2004 |
| Completion date | 01/01/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 30 |
| Key inclusion criteria | 1. Both males and females 2. Age 17-70 years 3. Patients scheduled for liver transplantation |
| Key exclusion criteria | Incapacity to comprehend the study protocol |
| Date of first enrolment | 01/08/2004 |
| Date of final enrolment | 01/01/2008 |
Locations
Countries of recruitment
- Switzerland
Study participating centre
Hopitaux Universitaires de Geneve
Geneva
1211
Switzerland
1211
Switzerland
Sponsor information
Geneva University Hospitals (Hôpitaux Universitaires de Genève) (Switzerland)
Hospital/treatment centre
Hospital/treatment centre
24 Micheli du Crest
Geneva
1211
Switzerland
| Website | http://www.hug-ge.ch |
|---|---|
"ROR" |
https://ror.org/01m1pv723 |
Funders
Funder type
Hospital/treatment centre
Geneva University Hospitals (Hôpitaux Universitaires de Genève) (Switzerland)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
