Reducing antibiotic prescribing in respiratory illness

ISRCTN	ISRCTN47558792
DOI	https://doi.org/10.1186/ISRCTN47558792
Protocol serial number	086921; UKCRN ID: 7412
Sponsor	The Wellcome Trust (UK)
Funder	Wellcome Trust

Submission date: 16/03/2010
Registration date: 17/03/2010
Last edited: 24/02/2015

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Respiratory

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Prof Martin Gulliford
Scientific

Division of Health and Social Care Research
Division of Primary Care and Public Health
King's College London
6th Floor Capital House
42 Weston Street
London
SE1 3QD
United Kingdom

Email	martin.gulliford@kcl.ac.uk

Study information

Primary study design	Interventional
Study design	Interventional multicentre cluster randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	Cluster randomised trial in a Primary Care database: utilising electronic patient records for intervention research into reducing antibiotic prescribing in respiratory illness
Study objectives	To test the effectiveness of an electronic record-based intervention at achieving a reduction in antibiotic prescribing at consultations for respiratory illness between the ages of ages 18 and 59 years in intervention practices as compared with controls.
Ethics approval(s)	London - Surrey Borders Research Ethics Committee, 21/12/2009, ref: 09/H0806/81
Health condition(s) or problem(s) studied	Respiratory tract infection
Intervention	Electronic prompts have been developed based on recommended clinical practice guidelines to be activated during consultations for respiratory tract infection (RTI) in the selected age range. During consultations with patients presenting with symptoms of RTI, primary care professionals will see the prompts which remind them of recommended standards of care in RTI. The prompts will also provide them with supporting information and links to evidence that supports the recommendations. The decision on whether to follow the treatment suggestions included in the prompt, or whether to prescribe antibiotics, will be at the discretion of the GP. The GP will also be able to terminate display of the prompt at any time. As indicated above, the prompts will only be activated during consultations by patients aged 18 to 59 years. There will be no intervention at control practices. The intervention phase will continue for 12 months at each practice.
Intervention type	Other
Primary outcome measure(s)	Proportion of RTI consultations with antibiotics prescribed over 12 months
Key secondary outcome measure(s)	Measured at 12 months follow-up: 1. Age- and sex-specific rates of RTI consultation 2. Age- and sex-specific proportion of RTI consultations with antibiotics prescribed 3. Occurrence of RTI complications
Completion date	31/10/2011

Eligibility

Participant type(s)	Patient
Age group	Adult
Lower age limit	18 Years
Upper age limit	59 Years
Sex	All
Target sample size at registration	100
Key inclusion criteria	1. Patients aged 18 - 59 years, either sex 2. Registered at the practice for at least 3 years at the trial start date 3. First diagnosis of stroke recorded in the 24-month period before the trial start date
Key exclusion criteria	Younger than 18 years and over the age of 59 years
Date of first enrolment	01/04/2010
Date of final enrolment	31/10/2011

Locations

Countries of recruitment

United Kingdom
England

Study participating centre

Division of Health and Social Care Research

London
SE1 3QD
United Kingdom

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	11/06/2014		Yes	No
Protocol article	protocol	10/05/2011		Yes	No
Other publications	process evaluation	03/12/2014		Yes	No
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes