Transcranial doppler sonography with a transorbital approach as a confirmatory test in the diagnosis of brain death
| ISRCTN | ISRCTN49093383 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN49093383 |
| Protocol serial number | N/A |
| Sponsor | Athens General Hospital "G. Gennimatas" (Greece) |
| Funder | Athens General Hospital "G. Gennimatas" (Greece) - Intensive Care Unit (ICU) Department |
- Submission date
- 26/09/2008
- Registration date
- 27/10/2008
- Last edited
- 27/10/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nervous System Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Andreas Karabinis
Scientific
Scientific
154 Mesogeion Ave
Athens
11527
Greece
| Phone | +30 21 0748 0188 |
|---|---|
| echolabicu@gmail.com |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | This study was designed to evaluate whether the routine addition of the transorbital doppler examination of the carotid siphon in patients suspected of brain death improves the efficiency of the transcranial doppler examination protocol. |
| Ethics approval(s) | The study was approved by the Institutional Ethics Committee of the General State Hospital of Athens in 2005 (ref: ICUTCD2005/2). |
| Health condition(s) or problem(s) studied | Brain death |
| Intervention | All patients underwent cerebral angiography, transcranial doppler examination of the basilar, anterior and middle cerebral arteries bilaterally. In addition, the patients in the intervention group were assessed by transorbital doppler of the carotid siphons bilaterally. |
| Intervention type | Other |
| Primary outcome measure(s) |
Blood flow patterns measured by transcranial doppler sonography with a suboccipital, transtemporal and transorbital approach. |
| Key secondary outcome measure(s) |
Efficacy of the transorbital approach in the diagnosis of brain death with transcranial doppler sonography. |
| Completion date | 31/07/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 79 |
| Key inclusion criteria | Brain dead patients of the intensive care unit (both males and females, aged greater than 16 years) who were hospitalised from October 2005 to July 2008. |
| Key exclusion criteria | 1. Patients with an episode of hypoxia or hypotension during the angiographic or transcranial doppler examinations 2. Patients with no flow at the initial transcranial doppler examination in any approach |
| Date of first enrolment | 01/10/2005 |
| Date of final enrolment | 31/07/2008 |
Locations
Countries of recruitment
- Greece
Study participating centre
154 Mesogeion Ave
Athens
11527
Greece
11527
Greece
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
