Attentional style in bipolar disorder

ISRCTN	ISRCTN50788919
DOI	https://doi.org/10.1186/ISRCTN50788919
Protocol serial number	5864
Sponsor	University of Oxford (UK)
Funder	The Wellcome Trust (UK)

Submission date: 12/05/2010
Registration date: 12/05/2010
Last edited: 11/08/2014

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Mental and Behavioural Disorders

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Catherine Harmer
Scientific

University Department of Psychiatry
Warneford Lane
Headington
Oxford
OX3 7JX
United Kingdom

Study information

Primary study design	Interventional
Study design	Single-centre interventional treatment trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	1. Do patients with bipolar disorder display an attentional bias towards threat? 2. Can this bias be modified using a simple computer-based intervention? 3. Does modifying the bias lead to changes in the emotional response to stressful situations?
Ethics approval(s)	MREC approved, ref: 08/H0603/36
Health condition(s) or problem(s) studied	Topic: Mental Health Research Network; Subtopic: Bipolar affective disorder; Disease: Bipolar affective disorder
Intervention	Intervention - positive attention training: this involves completing a computer-based task on the day of testing. The task requires that particiapnts pay less attention to negative information. Participants complete the task only during the testing session. The task takes approximately 30 minutes to complete. Control - neutral attention training: this is identical to the intervention task except that the participants are not required to direct their attention away from negative information. Study entry: registration and one or more randomisations.
Intervention type	Other
Primary outcome measure(s)	Attentional bias as measured using a computerised task (the dot-probe task) on the day of testing
Key secondary outcome measure(s)	1. Symptoms of anxiety, measured on a 10-point scale and collected via SMS messaging three times a day for the week following testing 2. Symptoms of low mood (measured using the Positive Affect Negative Affect Schedule [PANAS] scale) and anxiety (measured using the State-Trait Anxiety Inventory [STAI] scale) immediately following testing
Completion date	01/10/2011

Eligibility

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target sample size at registration	80
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	13/03/2009
Date of final enrolment	01/10/2011

Locations

Countries of recruitment

United Kingdom
England

Study participating centre

University Department of Psychiatry

Oxford
OX3 7JX
United Kingdom

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan