Towards rational prescribing of antibiotics for acute rhinosinusitis: evaluation of the impact and costs of implementation strategies based on a multidisciplinary evidence-based guideline
| ISRCTN | ISRCTN57375471 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN57375471 |
| Secondary identifying numbers | F6/12 - AV - F 681 |
- Submission date
- 18/03/2005
- Registration date
- 25/07/2005
- Last edited
- 15/04/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Respiratory
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Marc De Meyere
Scientific
Scientific
De Pintelaan 185 1K3
Ghent
B-9000
Belgium
| marc.demeyere@ugent.be |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | GP practice |
| Study type | Not Specified |
| Scientific title | |
| Study objectives | In Belgium consumption of antibiotics is among the highest in Europe. As a result antimicrobial resistance rates are alarming. Recently a number of evidence-based guidelines on rational use of antibiotics have been produced and disseminated by the scientific organisations in collaboration with the Belgian Co-ordinating Committee for Antibiotic Policy. International research has shown that merely distributing guidelines to professionals in the field does not lead to behaviour change. In Belgium several strategies for implementation of good clinical practice, i.e. local peer review groups and academic detailing, have been initiated. However, the (local) effectiveness and cost-effectiveness of these strategies has not been evaluated. This project will investigate the impact of each of the strategies separately and the combination of both strategies in general practice, following the publication of a guideline on the management of acute rhinosinusitis. This guideline aims at rationalizing (i.e. reducing) the prescription rate for this condition in primary care. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Implementation of a practice guideline for acute rhinosinusitis in general practice |
| Intervention | Cluster randomised factorial trial with 4 study arms. Interventions: academic detailing visits to individual GPs and/or group sessions of GPs on the key messages of the guideline. Control: no specific intervention |
| Intervention type | Other |
| Primary outcome measure | Antibiotic prescription rate, cost-effectiveness. |
| Secondary outcome measures | Choice of antibiotic, use of personalized non-drug prescriptions, clinical course of rhinosinusitis as reported in patient diaries. |
| Overall study start date | 01/07/2004 |
| Completion date | 30/06/2005 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 135 patient registrations are aimed for in each study arm |
| Key inclusion criteria | Local peer review groups of general practitioners in Flanders, Belgium (approximately 10-20 GPs per group) are invited to participate. |
| Key exclusion criteria | Groups that have participated in the field testing of the guideline, groups that have been visited by academic detailers more than once in the past, groups located at >1 hour drive from the study centres. |
| Date of first enrolment | 01/07/2004 |
| Date of final enrolment | 30/06/2005 |
Locations
Countries of recruitment
- Belgium
Study participating centre
De Pintelaan 185 1K3
Ghent
B-9000
Belgium
B-9000
Belgium
Sponsor information
Fund for Scientific Research, Flanders (Belgium)
Not defined
Not defined
Egmontstraat 5
Brussels
B-1000
Belgium
"ROR" |
https://ror.org/03qtxy027 |
|---|
Funders
Funder type
Government
Federal Belgian Ministry of Health and Fund for Scientific Research Flanders, Dossier nr. G.0617.05
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | Results: | 01/06/2007 | Yes | No |
