Acoustic analysis of the effect of codeine on cough in asthma and chronic obstructive pulmonary disease
| ISRCTN | ISRCTN57615270 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN57615270 |
| Protocol serial number | N0226093097 |
| Sponsor | Department of Health (UK) |
| Funder | North West Lung Centre Charity (UK) |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 12/05/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Respiratory
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Ashley Woodcock
Scientific
Scientific
North West Lung Centre
South Manchester University Hospitals NHS Trust
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom
| Phone | +44 (0)161 291 5873 |
|---|---|
| ashley.woodcock@manchester.ac.uk |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | 1. To validate cough programme in the clinical setting (both in hospital and in the home environment) 2. To determine the specificity and sensitivity of the technique 3. To develop the programme further using more advanced sound analysis to improve detection and recognition of cough 4. To test the programme's ability to detect the effect of codeine linctus |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Chronic obstructive pulmonary disease (COPD) |
| Intervention | Codeine phosphate 60 mg or matched placebo were given, in random order, at the start of each cough recording (0 and 12 hours). |
| Intervention type | Drug |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Codeine |
| Primary outcome measure(s) |
The number of coughs in each group before and after codeine, both in hospital and at home. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 31/05/2003 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 21 |
| Key inclusion criteria | 21 patients with physician-diagnosed, stable disease who complained of cough. |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/10/2002 |
| Date of final enrolment | 31/05/2003 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
North West Lung Centre
Manchester
M23 9LT
United Kingdom
M23 9LT
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | Results | 01/04/2006 | Yes | No |
