Oral antiviral prophylaxis for prevention of recurrent herpes simplex infection after corneal grafting - a pilot study

ISRCTN	ISRCTN58278320
DOI	https://doi.org/10.1186/ISRCTN58278320
Protocol serial number	N0141109779
Sponsor	Department of Health
Funder	Moorfields Eye Hospital NHS Trust (UK)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Mr Graham Lee
Scientific

Moorfields Eye Hospital
162 City Road
London
EC1V 2PD
United Kingdom

Phone	+44 (0)20 7253 3411

Primary study design	Interventional
Study design	Randomised placebo-controlled double-blind pilot study
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	What duration of oral valaciclovir antiviral prophylaxis is required to decrease the recurrence of herpes simplex corneal infection following corneal grafting performed for scarring from herpes simplex?
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Infections and Infestations: Herpes
Intervention	Valaciclovir vs placebo
Intervention type	Drug
Phase	Not Applicable
Drug / device / biological / vaccine name(s)	Valaciclovir
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	27/04/2005

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target sample size at registration	40
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	28/04/2002
Date of final enrolment	27/04/2005

Moorfields Eye Hospital

London
EC1V 2PD
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan