Comparison of two surgical techniques for eyebrow lifting

ISRCTN	ISRCTN58932744
DOI	https://doi.org/10.1186/ISRCTN58932744
Ethical approval from the Biomedical Research Ethics Committee at Damascus University	DN-28102025-546
Universal Trial Number (UTN) of WHO	U1111-1333-1088
Sponsor	Damascus University
Funder	Damascus University

Submission date: 18/12/2025
Registration date: 18/12/2025
Last edited: 18/12/2025

Recruitment status: Not yet recruiting
Overall study status: Ongoing
Condition category: Musculoskeletal Diseases

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Background and study aims
This study is looking at two different surgical techniques for lifting eyebrows. The goal is to find out which approach works best for improving eyebrow position and symmetry.

Who can participate?
Women aged 20 to 60 years old who have lowered eyebrows and do not have any systemic health conditions can take part.

What does the study involve?
Participants will have eyebrow lift surgery under local anesthesia at the hospital. After surgery, they will attend follow-up appointments after 1 week, 3 months, and 6 months to check progress.

What are the possible benefits and risks of participating?
The main benefit is improving the position and symmetry of the eyebrows. Risks include mild pain and swelling after surgery, which are usually manageable. There is also a small risk of scarring, but steps will be taken during surgery to reduce this.

Where is the study run from?
Oral and Maxillofacial Surgery Hospital, Faculty of Dentistry, Damascus University (Syria)

When is the study starting and how long is it expected to run for?
The study is planned to start on 12 January 2026. It will run until all 24 participants have completed their 6-month follow-up.

Who is funding the study?
Damascus University (Syria)

Who is the main contact?
For more information, please contact Dr. Osama Kashour.

Contact information

Dr Mohammed Osama Kashour
Principal investigator, Public

Building No 14, Almazzah street
Damascus
97001
Syria

ORCID ID	0009-0007-1235-5887
Phone	+963 991622352
Email	osamakashor1@gmail.com

Prof Khaldoun Darwich
Scientific

Building No. 1, Alabed street
Damascus
97001
Syria

Phone	+963 966195484
Email	Khaldoun.darwich@damascusuniversity.edu.sy

Study information

Primary study design	Interventional
Allocation	Randomized controlled trial
Masking	Blinded (masking used)
Control	Active
Assignment	Parallel
Purpose	Treatment
Scientific title	Comparison between two different surgical techniques to lift the lateral section of the eyebrow. Randomized clinical trial
Study objectives	To compare between the temporal surgical approach and the direct surgical approach for brow lifting.
Ethics approval(s)	Approved 28/10/2025, Biomedical Research Ethics Committee at Damascus University (Albaramkah, Damascus, 97001, Syria; +963 112134077; Prof.ahmadburhan@damascusuniversity.edu.sy), ref: DN-28102025-546
Health condition(s) or problem(s) studied	Eyebrow ptosis
Intervention	After taking a written consent, enrolled patients will be randomised via cards in sealed enveloped to be allocated into the temporal technique group or the direct brow lifting technique group. For the first group, patients will be anesthetized locally on both sides and a temporal incision will be made, followed by blunt dissection to reach the brow, the skin will be tightened and extra skin will be removed. Sutures will be made to close the wounds. In the direct brow technique, local anesthesia will be applied bialterally, followed by incision directly above the brow (from the middle of the brow to the lateral side) in a triangular pattern, followed by blunt dissection and removing extra skin. Finally, sutures will be made.
Intervention type	Procedure/Surgery
Primary outcome measure(s)	Position of the eyebrow measured using Distance between Ala of the nose and the end part of the nose, and the distance between Ala of the nose and the highest point of the brow in millimeters. Photographs will be taken at all time points at Before surgery (baseline), 1 week after surgery , 3 months, and 6 months Crow's feet grading scale measured using 5 point photonumeric scale at static and dynamic states (at rest and with expression) at Before surgery, 1 week after surgery, 3 months, and 6 months
Key secondary outcome measure(s)	Patient satisfaction measured using Questionnaire at Before surgery and at 6 months Adverse effects measured using Patient reported side effects at Any time following the surgery
Completion date	31/08/2026

Eligibility

Participant type(s)
Age group	Adult
Lower age limit	20 Years
Upper age limit	50 Years
Sex	Female
Target sample size at registration	24
Key inclusion criteria	1. Women with an age range between 20-50 years old 2. Patients with brow ptosis 3. Patients who had never been subjected to eyebrow liftin surgery 4. Patients with pseudo-plepharoptosis 5. Cooperative patients
Key exclusion criteria	1. Uncontrolled systematic diseases 2. Patients who has brow ptosis due to plepharoptosis 3. Patients who were subjected to previous eyebrow lifting surgeries 4. Patients with a history of severe hypertrophic and keloid scars
Date of first enrolment	12/01/2026
Date of final enrolment	24/02/2026

Locations

Countries of recruitment

Syria

Study participating centres

Results and Publications

Individual participant data (IPD) Intention to share	Yes
IPD sharing plan summary	Available on request
IPD sharing plan	The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request

Editorial Notes

18/12/2025: Trial's existence confirmed by Damascus University.