The role of radical surgery in advanced epithelial ovarian cancer

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr - -
Scientific

UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
London
NW1 2DA
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Study type	Participant information sheet
Scientific title	The role of radical surgery in advanced epithelial ovarian cancer
Study objectives	Not provided at time of registration
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Ovarian cancer
Intervention	Patients are randomised to one of two treatment arms: 1. Arm A: High activity platinum based chemotherapy. The recommended chemotherapy regimen is cyclophosphamide and cisplatin given for a maximum of eight cycles. 2. Arm B: Radical debulking surgery followed by chemotherapy as described above.
Intervention type	Mixed
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	31/12/1995

Participant type(s)	Patient
Age group	Not Specified
Sex	Female
Key inclusion criteria	1. Histologically confirmed epithelial ovarian cancer 2. Macroscopic residual disease unlikely in surgeon's opinion to be completely debulked without bowel resection or other procedures 3. No attempt to radically debulk 4. No prior chemotherapy or radiotherapy 5. No previous or concurrent malignancy other than non melanomatous skin cancer 6. No haematological or biochemical contra-indication to platinum chemotherapy 7. No contraindication to second laparotomy 8. Available to commence chemotherapy or undergo further surgery within 6 weeks of diagnostic laparotomy
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/01/1990
Date of final enrolment	31/12/1995

MRC Clinical Trials Unit

London
NW1 2DA
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Participant information sheet	Participant information sheet	11/11/2025	11/11/2025	No	Yes

30/10/2019: No publications found, all search options exhausted, study status unverified.