Angiotensin-converting enzyme (ACE) genotype and mechanical efficiency of human skeletal muscle: a double blind cross over trial of the effect of low dose ACE inhibitor on claudication

ISRCTN	ISRCTN65334644
DOI	https://doi.org/10.1186/ISRCTN65334644
Protocol serial number	N0263132923
Sponsor	Department of Health
Funder	University College London Hospitals NHS Trust (UK)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Mr E Chaloner
Scientific

Department of Surgery
Charles Bell House
67-73 Riding House Street
London
W1W 7EJ
United Kingdom

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	Does ACE genotype of an individual affect the degree to which exercise treatment improves claudication and can this effect be improved by use of low dose ACE inhibitor?
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Surgery: Cardiovascular
Intervention	1. Drug (Ramipril) 2. Placebo
Intervention type	Drug
Phase	Not Specified
Drug / device / biological / vaccine name(s)	ramipril
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	31/07/2007

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target sample size at registration	60
Key inclusion criteria	Not provided at time of registration
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/11/2003
Date of final enrolment	31/07/2007

Department of Surgery

London
W1W 7EJ
United Kingdom

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan