The N-methyl-D-aspartate (NMDA)-antagonist memantine affects training induced motor cortex plasticity: a study using transcranial magnetic stimulation
| ISRCTN | ISRCTN65784760 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN65784760 |
| Protocol serial number | N/A |
| Sponsor | BG-Kliniken Bergmannsheil (Germany) - Department of Neurology |
| Funders | BG-Kliniken Bergmannsheil (Germany) - Department of Neurology; main funders, Merz Pharmaceuticals GmbH (Germany) - funded the measurement of the memantine serum levels |
- Submission date
- 06/05/2005
- Registration date
- 09/05/2005
- Last edited
- 15/02/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Other
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Martin Tegenthoff
Scientific
Scientific
Department of Neurology
BG-Kliniken Bergmannsheil
Buerkle-de-la-Camp-Platz 1
Bochum
44789
Germany
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Training induced motor cortex plasticity |
| Intervention | Memantine versus placebo either given as a single dose or daily over 8 days. |
| Intervention type | Drug |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Memantine |
| Primary outcome measure(s) |
The differential effects of different treatment regimens. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 31/01/2005 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 20 |
| Key inclusion criteria | Healthy subjects (adults, either sex) |
| Key exclusion criteria | 1. Left-handedness 2. Neurological disorders 3. Intake of central acting drugs |
| Date of first enrolment | 01/06/1998 |
| Date of final enrolment | 31/01/2005 |
Locations
Countries of recruitment
- Germany
Study participating centre
Department of Neurology
Bochum
44789
Germany
44789
Germany
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | Results | 12/05/2005 | Yes | No |
