Psychotherapy for residual depression following initial treatment: effectiveness, relapse prevention and mechanisms of change
| ISRCTN | ISRCTN67561918 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN67561918 |
| Protocol serial number | N/A |
| Sponsor | University Maastricht (UM) (The Netherlands) |
| Funder | University Maastricht (UM) (The Netherlands) |
- Submission date
- 16/01/2007
- Registration date
- 16/01/2007
- Last edited
- 22/11/2011
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Mental and Behavioural Disorders
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Heleen van Teeseling
Scientific
Scientific
University Maastricht (UM)
Department of Medical, Clinical and Experimental Psychology
P.O. Box 616
Maastricht
6200 MD
Netherlands
| h.vanteeseling@dmkep.unimaas.nl |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised, controlled, parallel group trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study acronym | STEP-D |
| Study objectives | Are Cognitive Behavioural Therapy (CBT) and InterPersonal Therapy (IPT) following initial treatment effective interventions that prevent relapse of recurrence of depression in the long-term? What are the mechanisms of change in CBT and IPT? |
| Ethics approval(s) | Approval received from the local ethics committee (Medisch Ethische Commissie azM/UM) on the 5th December 2006 (ref: MEC 06-3-063). |
| Health condition(s) or problem(s) studied | Depression |
| Intervention | 1. Cognitive Behaviour Therapy (CBT), N=75 2. InterPersonal Therapy (IPT), N=75 3. Eight-week waiting list, N=30 CBT= max. 20 sessions IPT= max. 20 sessions All interventions are delivered by qualified therapists under supervision at the Academic Riagg Maastricht. |
| Intervention type | Other |
| Primary outcome measure(s) |
Depressive relapse/recurrence in the course of 24 months. |
| Key secondary outcome measure(s) |
1. Severity of depression (BDI) |
| Completion date | 01/08/2011 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target sample size at registration | 180 |
| Key inclusion criteria | 1. One or more episodes of Major Depressive Disorder (MDD) in past two years 2. Initial treatment for depressive symptoms 3. Residual symptoms of depression (Beck Depression Inventory [BDI] more than or equal to ten) |
| Key exclusion criteria | 1. Chronic depression 2. Concurrent treatment for depression 3. Severe co-morbidity 4. Medical conditions that explain depressive symptoms |
| Date of first enrolment | 01/08/2006 |
| Date of final enrolment | 01/08/2011 |
Locations
Countries of recruitment
- Netherlands
Study participating centre
University Maastricht (UM)
Maastricht
6200 MD
Netherlands
6200 MD
Netherlands
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol article | protocol | 14/06/2011 | Yes | No | |
| Study website | Study website | 11/11/2025 | 11/11/2025 | No | Yes |
