First line therapy for uncomplicated falciparum malaria with Coartem® and Coarsucam® in Burkina Faso

The following will be assessed at 28 days:
1. Risk of recurrent malaria
2. Risk of recurrent parasitaemia
3. Risk of clinical treatment failure
4. Risk of parasitological treatment failure

1. Prevalence of fever (defined as both subjective fever in the previous 24 hours and measured axillary temperature greater than 37.5°C) on follow-up days 1, 2, and 3
2. Prevalence of parasitaemia on follow-up days 2 and 3
3. Change in mean haemoglobin from day 0 to 28 (or day of rescue therapy for patients classified as late clinical failure [LCF] or late parasitological failure [LPF])
4. Prevalence of gametocytaemia and gametocyte density on follow-up days 2, 3, 7, 14, 21, 28
5. Risk of serious adverse events: proportion of patients experiencing any serious adverse event in each treatment group during the 28-day follow-up period (both including and excluding patients classified as early treatment failure [ETF] or LCF, as recurrent malaria can be confounding)
6. Risk of adverse events of moderate or greater severity, at least possibly related to the study medications (both including and excluding patients classified as ETF or LCF)
7. Change in the prevalence of molecular markers associated with drug resistance from day 0 to the day of recurrent parasitaemia